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Experimental studies of the abuse potential of racemic glaucine 1 5 phosphate in rhesus monkeys


, : Experimental studies of the abuse potential of racemic glaucine 1 5 phosphate in rhesus monkeys. Pharmacology Biochemistry & Behavior 16(5): 851-854

d-Glaucine is an alkaloid derived from Glaucium flavum, which is as effective as codeine as an antitussive. d,l-Glaucine-1,5-phosphate is a synthetic compound related to d-glaucine. The ability of d,l-glaucine-1,5-phosphate to maintain responding in rhesus monkeys [Macaca mulatta] was assessed in 2 procedures. In the 1st study responding was maintained under a fixed-ratio 10 schedule of codeine delivery during daily 3-h sessions. When d,l-glaucine-1,5-phophate (0.05-0.4 mg/kg) was substituted for codeine, responding was not maintained. In the 2nd procedure, monkeys given 23-h day access to 0.5-1.0 mg/kg under a fixed-ratio schedule did not self-administer d,l-glaucine-1,5-phosphate above saline levels even after a 21-day period of programmed injections. Following the period of programmed injections, there were no signs of opiate withdrawal following the administration of naloxone. Evidently, the abuse potential of d,l-glaucine-1,5-phosphate is low relative to codeine.

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