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Experimental study of the effect of poly saccharide mannan on some biochemical blood lymph and serum indices


, : Experimental study of the effect of poly saccharide mannan on some biochemical blood lymph and serum indices. Antibiotiki (Moscow) 26(10): 756-761

The effect of mannan, a polysaccharide of microbial origin, on the content of protein fractions, total protein, glucose, cholesterol (total, free and bound) urea, urea N and residual N in the lymph and serum was studied in rabbits. Mannan was administered i.m. in a 0.6% solution in single doses of 0.6-6 mg/kg and repeatedly in doses of 0.6-3 mg/kg for 3-49 days. The lymph specimens were collected from the thoracic duct 1 and 24 h after mannan administration. In any dose administered once, mannan induced an increase in the content of .gamma.-globulin in the lymph and no increase in the blood serum, characterized by changes in the ratio of the other protein fractions. No other changes in the biochemical indices of the lymph and serum in the experimental animals were noted. When used repeatedly, mannan had no effect on the content of protein fractions in the lymph and serum. The study on changes in the biochemical indices of the lymph provided additional data on the character of the mannan effect in the host.

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