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Factors affecting cardio vascular responses to stimulation of hypothalamus in the rat

, : Factors affecting cardio vascular responses to stimulation of hypothalamus in the rat. Experimental Neurology 51(1): 188-206

Changes in heart rate and arterial pressure to electrical stimulation of 161 histologically verified sites in the hypothalamus and preoptic area were investigated in 60 artificially respired rats under chloralose anesthesia. Stimulation at 80 Hz of most nuclei of the posterior hypothalamus elicited hypertension and bradycardia; stimulation of sites in these nuclei in vagotomized rats elicited hypertension and tachycardia. Stimulation of the dorsomedial and premamillary nuclei often elicited hypotension and bradycardia; stimulation of these nuclei in vagotomized rats elicited hypertension and tachycardia. Hypertension elicited from the lateral and anterior hypothalamus by 80-Hz stimulation was eliminated or was changed to hypotension during stimulation at 8 Hz. Hypotension and bradycardia elicited from the ventral preoptic area were changed to hypertension and tachycardia after vagotomy; bradycardia, but not hypotension, elicited from the dorsal preoptic area was abolished by vagotomy or methyl atropine administration. Responses elicited from 54 sites in 31 urethane-anesthetized rats were similar to those elicited from vagotomized chloralose-anesthetized rats. Accurate localization of stimulation sites, stimulation parameters and anesthetic agents are important in studies of central neural control of the cardiovascular system.


PMID: 1261634

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