+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Failure of angiotensin ii to stimulate increases in concentrations of adrenal androgens 17 hydroxy progesterone or acth in congenital 21 hydroxylase deficiency

, : Failure of angiotensin ii to stimulate increases in concentrations of adrenal androgens 17 hydroxy progesterone or acth in congenital 21 hydroxylase deficiency. Journal of Clinical Endocrinology & Metabolism 56(3): 627-631

To determine if angiotensin II stimulates an increase in the plasma concentration of androstenedione, dehydroepiandrosterone, 17-hydroxyprogesterone or ACTH in a patient with congenital 21-hydroxylase deficiency, these plasma concentrations were measured before and after the plasma angiotensin II concentration was increased by upright posture and angiotensin II infusion in a surgically castrate XX adult patient with this disorder. The patient was studied before treatment, after treatment with 1 mg dexamethasone daily for 3 wk, and after treatment with both dexamethasone and 0.2 mg fluorocortisone daily for 3 wk. The plasma concentrations of androstenedione, dehydroepiandrosterone and 17-hydroxyprogesterone did not change consistently during increases in the angiotensin II concentration. The ACTH concentration did not increase in response to raised angiotensin II concentrations before or after steroid treatment. During the infusion of angiotensin II, blood pressure increased and renin activity decreased, appropriate in degree to the preinfusion concentration of angiotensin II. The results from the study of this patient do not support the hypotheses that in congenital 21-hydroxylase deficiency, angiotensin II directly stimulates adrenal androgen secretion, or that angiotensin II stimulates ACTH secretion.


Other references

Wieder, H., 1977: On being told of adoption. Clinical data from the analyses of three adoptees document the deleterious effect of telling children under three years of age about their adoptive status. The knowledge, as well as the experiences, of being an adoptee imposes the need for defensi...

Malterre, M., 1969: Cryoextraction of the crystalline lens: commentary on 100 cases. Bulletin des Societes D'ophtalmologie de France 69(4): 501-506

Forbes, M.A.; Wilson, B.P.; Greenhalgh, R.; Cochrane, W.P., 1975: Confirmation of organophosphorus insecticides by chemical reduction. Bulletin of Environmental Contamination and Toxicology 13(2): 141-148

Smith, K.L.Jr.; Kaufmann, R.S.; Wakefield, W.W., 1993: Mobile megafaunal activity monitored with a time-lapse camera in the abyssal North Pacific. Epibenthic megafauna comprise a large fraction of the deep-sea benthic biomass and are considered important in bioturbation and sediment mineralization processes. However, the sparse and often patchy distribution of these animals makes them diffic...

Borges, M.; Silva, A.C. da; Sereno, D.; Ouaissi, A., 2003: Peptide-based analysis of the amino acid sequence important to the immunoregulatory function of Trypanosoma cruzi Tc52 virulence factor. The intracellular protozoan parasite Trypanosoma cruzi is the aetiological agent of Chagas' disease. We have previously identified a T. cruzi-released protein called Tc52, which is crucial for parasite survival and virulence. In the present s...

Vollenweider, R.A., 1962: On the use of conductomet-ric procedures for the determination of total alkalinity, chlorides and sulfates in freshwater. Alkalinity and chloride estimates are considerably improved with conductometric titrations; alkalinity values, even as low as 0.05 mval/l and chloride content to 0.5 mg/l may be obtained with high precision and accuracy. An indirect procedure for...

Knight, A.W.; Nebeker, A.V.; Gaufin, A.R., 1965: Description of the eggs of common Plecoptera of western UnitedStates. Drawings of eggs of 25 species of common Plecoptera of western United States, a table listing color, shape, and size of the egg of each given species and a brief discussion of methods and materials is included.

Dirig, Robert., 1994: Historical notes on wild lupine and the Karner blue butterfly at the Albany Pine Bush, New York. Unknown

Legendre, L.; L.F.vre, J., 1995: Microbial food webs and the export of biogenic carbon in oceans. Microbial food webs, which comprise phototrophic picoplankton (or ultraplankton), heterotrophic bacteria and protozoa, are ubiquitous in marine waters. Members of the microbial food web may play various roles in the export of biogenic carbon. For...

Shefet, S.M.; Sheldon, B.W.; Klaenhammer, T.R., 1995: Efficacy of optimized nisin-based treatments to inhibit Salmonella typhimurium and extend shelf life of broiler carcasses. Nisin is an antimicrobial peptide produced by Lactococcus lactis subsp. lactis. Nisin exhibits a broad spectrum of inhibitory activity against gram-positive microorganisms such as Listeria monocytogenes and Clostridium botulinum. In previous studi...