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Flow and diffusion of indocyanine green and fluorescein dyes in the fovea centralis


, : Flow and diffusion of indocyanine green and fluorescein dyes in the fovea centralis. Experimental Eye Research 24(1): 15-23

Fluorescein, a diffusible dye, and indocyanine green, a non-diffusible reference substance, were injected into the circulatory system of healthy human subjects with normal ocular functions. A fundus reflectometer simultaneously measured the time course of fluorescence intensity of the fluorescein and the IR absorption of indocyanine green in the fovea centralis. The fluorescein curve represented both the intravascular passage of the dye and its diffusion into the foveal tissue. The indocyanine green curve represented only the intravascular passage of indocyanine green dye. The difference between the 2 curves provides information on the accumulation of fluorescein in the macula. The characteristics of the fluorescein and indocyanine green curves were determined for subjects with various degrees of ocular pigmentation.

US$19.90

PMID: 838000

DOI: 10.1016/0014-4835(77)90280-9


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