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Functional interaction and partial homology between human immunodeficiency virus and neuroleukin


, : Functional interaction and partial homology between human immunodeficiency virus and neuroleukin. Science 237(4818): 1047-1051

Dementia is common in patients with AIDS, but the mechanism by which the human immunodeficiency virus type 1 (HIV-1) causes the neurological impairment is unknown. In this study the possibility that an antigen of HIV-1 suppresses neuronal responses to neurotrophic factors was examined. Both HIV-1 and a related retrovirus, simian immunodeficiency virus (SIV), inhibited the growth of sensory neurons from chick dorsal root ganglia in medium containing neuroleukin (NLK) but not in medium containing nerve growth factor. An unrelated type D retrovirus, simian acquired immunodeficiency syndrome virus, did not affect the growth of neurons in the presence of either neurotrophic factor. The inhibition by HIV-1 of neuron growth in the presence of NLK was found to be due to the gp120 envelope glycoprotein. Regions of sequence homology between gp120 and NLK may account for this inhibitory property of gp120 and functional interactions between gp120 and NLK may be important in the pathogenesis of the AIDS dementia complex.

US$19.90

PMID: 3039662

DOI: 10.1126/science.3039662


Other references

Vincent, J.L.; Sakr, Y.; Ranieri, V.M., 2003: Epidemiology and outcome of acute respiratory failure in intensive care unit patients. To summarize the prevalence of various forms of acute respiratory failure in acutely ill patients and review the major factors involved in the outcome of these patients. MEDLINE search for published studies reporting the prevalence or outcome for...

Brown, C.S.; Sheridan, R.J., 2015: Case study illustrating risks of garrison unit watch for soldiers at risk of suicide. Unit watch over suicidal patients by nonmedical soldiers is often necessary in a deployed environment, but this strategy's risks may outweigh its benefits in a garrison environment. This case study illustrates risks of unit watches that are d...

Bakhotmah, M.A.; Ghabrah, T.M., 1997: The prevalence of asymptomatic gallbladder stones in patients with diabetes mellitus. Objectives: To study the prevalence of asymptomatic gallstones in patients with diabetes mellitus (DM) and to determine the risk factors for the occurrence of asymptomatic gallstones among diabetics. Methods: In a cross-sectional study design, 511...

Pearson A.J., 1981: New approach to aspidospermine total synthesis using organo iron complexes. Tetrahedron Letters 22(40): 4033-4036

Rhodes P.G.; Patel D.M.; Campbell S.B.; Graves G.R.; Blumenthal B.I., 1981: Respiratory care in hyaline membrane disease prevention of broncho pulmonary dysplasia. Clinical Research 29(5): 899A

Biel, H.; Bohn, H.; Ronneberger, H.; Zwisler, O., 1971: Speeding wound healing by blood clotting factor XIII. Arzneimittel-Forschung 21(10): 1429-1430

Lewis W.H.; Elvin Lewis M.; Gnerre M.C., 1987: Ethnobotanical pharmacopeia of the amazonian jivaro of peru. International Botanical Congress Abstracts 17: 292

Machado, L.F.; Laugesen, S.; Botelho, E.D.; Ricart, C.A.O.; Fontes, W.; Barbaro, K.C.; Roepstorff, P.; Sousa, M.V., 2005: Proteome analysis of brown spider venom: identification of loxnecrogin isoforms in Loxosceles gaucho venom. Brown spiders of the Loxosceles genus are distributed worldwide. In Brazil, eight species are found in Southern states, where the envenomation by Loxosceles venom (loxoscelism) is a health problem. The mechanism of the dermonecrotic action of Loxo...

Spanswick, R.M., 1972: Electrical coupling between cells of higher plants: A direct demonstration of intercellular communication. Electrical coupling between adjacent cells of Elodea canadensis has been demonstrated using a microelectrode technique in which the membrane potentials were recorded during the passage of a current pulse from the vacuole of one cell to the externa...

Anonymous, 1986: Re: Kidney stone removal: percutaneous versus surgical lithotomy. Journal of Urology 135(4): 812-812