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Gas liquid chromatography determination of doxepin plasma levels


, : Gas liquid chromatography determination of doxepin plasma levels. Journal of Pharmaceutical Sciences 65(7): 1068-1069

A procedure is described for extracting doxepin, a tricyclic antidepressant, from [human] plasma and subsequently measuring its concentration by GLC. The developed technique permits the resolution and quantitative determination of the cis- and trans-isomers of doxepin as well as its desmethyl metabolite. The method allows precise, reliable measurement of the drug and 1 of its metabolites in concentrations as low as 10 ng/ml of plasma.

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