geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Genetic control of red cell osmotic fragility


, : Genetic control of red cell osmotic fragility. Journal of Heredity 76(1): 31-35

Among normal mouse strains, natural genetic variation offers the potential to investigate the structure and function of cell membranes. One such polymorphism between C57BL/6J and DBA/2J is a difference in erythrocyte sensitivity to osmotic lysis. The genetic basis for erythrocyte osmotic fragility differences between mouse strains C57BL/6 and DBA/2 was examined through analyses of their serial backcross progeny, recombinant inbred (ri) strains (BXD), and congenic C57BL/6 strains with allelic differences at Hbb or Fv-2. The data indicate that the fragility difference between C57BL/6 and DBA/2 is the result of allelic differences at a minimum of two segregating loci. One of these might be linked to, but is not identical with the gene encoding the beta chain of hemoglobin (Hbb). Allelic differences at Fv-2, a gene known to control the proportion of erythroid precursors in the S phase, and at Hba, the structural locus of hemoglobin alpha chain also appear to exert no major influence on red cell osmotic fragility. Furthermore, the fact that red cells from one of the RI strans (BXD-31) are strikingly more resistant than those from the resistant parental strain DBA/2 leads to the conclusion that the degree of resistance/susceptibility for either strain is determined by the combined contributions of gene effects not all of which act in the same direction. We also found that red cells from strans C57BL/6 and DBA/2 differ in their uptake of 51Cr. This result suggests the possibility that red cell osmotic fragility differences may be due in part to differences in ion metabolism or membrane transport.

US$29.90

PMID: 3980972


Other references

Rinnert, H.; Thirion, C.; Dupont, G.; Lematre, J., 1977: Structural studies on aqueous and hydroalcoholic solutions of a polyene antibiotic: amphotericin B. Biopolymers 16(11): 2419-2427

Cole, Jonathan, 1988: Diptera of Huntingdonshire (17). Huntingdonshire Fauna and Flora Society Annual Report 40: 21-23

Hill, B.D.; Stobbe, E.H., 1978: Effect of light and nutrient levels on 14C-benzoylprop-ethyl metabolism and growth inhibition in wild oat (Avena fatua L.). Wild oat plants were dosed hydroponically with 14C-benzoylprop-ethyl and were grown under different light and nutrient levels. Herbicide metabolism and growth inhibition in plant shoots were measured after 3, 6 and 12 days. Plants under low light...

Tsuchi, R., 1970: A note on Mollusca dredged from Suruga Bay, thePacific side of central Japan. Rep. lib. Arts Sci. Fac. Shizuoka Univ. 2: 1958: 69-76

Cheong, W.H., 1968: A note on the interesting eggs of Aedes aurantius. Medical Journal of Malaya 22(3): 242-242

Anonymous, 1973: Civil War medicine. Aorn Journal 18(3): 637-642

Petkov, G.; Fusi, F.; Boev, K., 1995: Effects of cyclopiazonic acid on the phasic and tonic contractions in the smooth muscles of the guinea-pig and cat stomach. Dokladi na B"lgarskata Akademiya na Naukite 48(8): 57-60

Todd E Dawson; James R Ehleringer, 1993: Isotopic enrichment of water in the woody tissues of plants; implications for plant water source, water uptake, and other studies which use the stable isotopic composition of cellulose. The stable hydrogen isotopic ratio (D) of stem water is shown to deviate from source water values in young, nonsuberized woody stems, reflecting an isotopic enrichment associated with cuticular water loss and/or transpiration. The extent of this e...

Le, B.; Matulewicz, R.S.; Eaton, S.; Perry, K.; Nadler, R.B., 2014: Comparative analysis of vascular bulldog clamps used in robot-assisted partial nephrectomy. During robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN), clamping of the vascular pedicle before excision of the tumor is the key to minimize blood loss and maintain adequate visualization. Multiple options for...

Bamberger, P.A.; Koopmann, J.; Wang, M.; Larimer, M.; Nahum-Shani, I.; Geisner, I.; Bacharach, S.B., 2017: Does College Alcohol Consumption Impact Employment Upon Graduation? Findings From a Prospective Study. Although scholars have extensively studied the impact of academic and vocational factors on college students' employment upon graduation, we still know little as to how students' health-related behaviors influence such outcomes. Focusing...