geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Glucagon, insulin, cortisol, and growth hormone levels following major surgery: their relationship to glucose and free fatty acid elevations


, : Glucagon, insulin, cortisol, and growth hormone levels following major surgery: their relationship to glucose and free fatty acid elevations. Hormone and Metabolic Research 10(6): 465-470

Circulating hormone and substrate levels were measured in 7 patients at regular intervals before, during and after pulmonary surgery. During surgery, cortisol and growth hormone were significantly elevated, pancreatic glucagon was unchanged and insulin was depressed. One and two days after surgery, growth hormone had almost returned to preoperative fasting values, but cortisol, insulin and glucagon levels were significantly increased. The mean insulin:glucagon molar ratio declined from a preoperative fasting value of 3.2 +/- 0.5 (+/- SEM) to 1.7 +/- 0.4 during operation but was within normal limits 1 and 2 days after surgery due to a parallel rise and fall in plasma insulin and glucagon. Plasma glucose was elevated both during operation and for several days thereafter, whereas free fatty acid levels were increased only during operation. Thus, there was no consistent relation between insulin:glucagon ratio or any of the hormone levels and the observed elevations in plasma glucose and free fatty acids. It is concluded that neither any of the hormones assayed nor the insulin:glucagon ratio was the primary determinant of plasma glucose and free fatty acid responses to surgery. Rather, fuel homeostasis appeared to result from the combined effects of glucagon, insulin, growth hormone, cortisol and adrenergic activity.

US$19.90

PMID: 744565

DOI: 10.1055/s-0028-1093372


Other references

Perry, L.G.; Blumenthal, D.M.; Monaco, T.A.; Paschke, M.W.; Redente, E.F., 2010: Immobilizing nitrogen to control plant invasion. Increased soil N availability may often facilitate plant invasions. Therefore, lowering N availability might reduce these invasions and favor desired species. Here, we review the potential efficacy of several commonly proposed management approache...

Brzaković, P.; Svilarić, V., 1975: Radiotherapy of benign dermatosis. Srpski Arhiv Za Celokupno Lekarstvo 103(12): 1129-1137

Braun, V.; Pramanik, A.; Gwinner, T.; Köberle, M.; Bohn, E., 2009: Sideromycins: tools and antibiotics. Sideromycins are antibiotics covalently linked to siderophores. They are actively transported into gram-positive and gram-negative bacteria. Energy-coupled transport across the outer membrane and the cytoplasmic membrane strongly increases their a...

Cohn, David V., 1963: Effect of parathyroid extract on CO2 production by bone. FED PROC 22(2 Pt 1): 647

Kuznicki J.T.; Ashbaugh N., 1982: Space and time separation of taste mixture components. Under natural conditions, all component qualities of taste mixtures co-exist in space and time on the tongue surface. The significance of space-time coherenbce of taste sensations was investigated by separating mixture components on the tongue. Fi...

Félix, A-E.; Genestier, G.; Malosse, C.; Calatayud, P-A.; L.R., B.; Silvain, J-F.; Frérot, B., 2009: Variability in pheromone communication among different haplotype populations of Busseola fusca. The relationship between pheromone composition and mitochondrial haplotype clades was investigated by coupling DNA analyses with pheromone identification and male mate searching behavior among different geographic populations of Busseola fusca. Th...

Anonymous, 2001: Women, minorities with AIDS less likely to get new treatment. A Brown University study concluded that white and/or and male AIDS patients receive protease inhibitor treatment at a higher rate than women or minorities. For example, 75 percent of men and only 50 percent of women were given protease inhibitors....

Caplan, C.M., 1982: When to lease and when to buy dental equipment. Dental Management 22(8): 34-6, 38, 40

Huang, Z-shi.; Shi, F.; Fu, D-hong.; Su, Y-he.; Lu, W-li., 2011: Expression of PTEN, matrix metaloproteinases 2 and 9 in thymomas. To evaluate the expression of PTEN, MMP-2 and MMP-9 in thymomas and their correlation with clinical significance. Immunohistochemical S-P assay was used to detect the expression of PTEN, MMP-2 and MMP-9 in 45 thymomas and 16 non-neoplastic thymuse...

Stoepel, K., 1971: Antihypertensive activities of combinations os musculotropic peripheral vasodilators with reserpine. Arzneimittel-Forschung 21(1): 54-57