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Growth hormone releasing factor somatocrinin stimulates release of neurotensin calcitonin and cyclic amp by a rat c cell line

, : Growth hormone releasing factor somatocrinin stimulates release of neurotensin calcitonin and cyclic amp by a rat c cell line. Biochemical & Biophysical Research Communications 123(2): 497-506

GRF [growth hormone releasing factor] stimulates release of neurotensin (NT) by a clonal line of rat C cells (44-2 C). GRF stimulates calcitonin (CT) and cAMP release in these cells. For release experiments, replicate cultures are incubated for 5-180 min in serum-free defined medium. CT, NT and cAMP are measured by RIA. At a maximally effective concentration of GRF (0.1-1.0 nM), there is a 2- to 3-fold stimulation of CT release at 60-90 min with peak release at 180 min. GRF causes a rapid 4- to 6-fold increase of NT release within 5-15 min. In 44-2 C cells there is a 4- to 40-fold stimulation of cAMP release by GRF. In 44-2 C cells GRF stimulates release of NT and cAMP and show for the 1st time the effect of this peptide on release of CT.


Other references

Rasmussen, I., 1989: Cod-liver oil ointment and damask for gunshot wounds. Interview by Siv Barstad Heide. Journalen Sykepleien 77(19b): 38-39

Kobasigawa, A., 1965: Observation Of Failure In Another Person As A Determinant Of Amplitude And Speed Of A Simple Motor Reponse. Journal of Personality and Social Psychology 1: 626-630

Hamilton, H.I.; McLaughlin, S.A.; Whitley, E.M.; Gilger, B.C.; Whitley, R.D., 1994: Histological findings in corneal stromal abscesses of 11 horses: correlation with cultures and cytology. Histopathology was compared to culture results and cytology from horses with corneal stromal abscess at the Auburn University and the Ohio State University Veterinary Teaching Hospitals. Significant bacteria were not isolated in culture or seen on...

Necrasov, O., 1956: Contribution a l'etude de la structure microscopique du sac vasculaire des poissons osseux. Analele Stiintifice de Universitatii Al I Cuza NS 2: 2: 73-117

Wang, C.; Qiu, X.; Lv, L.; Huang, J.; Li, S.; Lou, T.; Liu, X., 2016: Chronotherapy for hypertension in patients with chronic kidney disease: a systematic review and meta-analysis in non-black patients. To investigate the effects of chronotherapy on blood pressure in patients with chronic kidney disease (CKD). We searched PUBMED, EMBASE, ASN-ONLINE, the Cochrane Library and the reference articles of published papers without language restriction,...

Gwynn C., 1937: The frontiers of Abyssinia. Journal of the Royal African Society 36(1937

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Hughes Richard John Jr., 1961: Nemocardium nicolleti from the Paleocene Matthews Landing Marl in Mississippi. Pelecypods, variously called as time went on, Cardium, then Protocardia, and then Nemocardium, have been described and figured from localities in the Gulf Coastal Plain since 1854. In the present article, for the first time, a specimen of Nemocard...

Otani, Y.; Igarashi, N.; Yokoyama, T.; Ishikawa, H.; Sakurai, Y.; Kameyama, K.; Kubota, T.; Kumai, K.; Hosoda, Y.; Kitajima, M., 1997: Role of matrix metalloproteinases in gastric ulcer formation. Gastroenterology 112(4 SUPPL ): A248