+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Hemodynamic effects of captopril in chronic heart failure efficacy of low dose treatment and comparison with prazosin

, : Hemodynamic effects of captopril in chronic heart failure efficacy of low dose treatment and comparison with prazosin. American Heart Journal 104(5 PART 2): 1164-1171

The acute hemodynamic effects and long-term therapeutic actions of low doses of the oral angiotensin-converting enzyme (ACE) inhibitor captopril (CPT) were evaluated in 18 patients with severe chronic congestive heart failure (CHF). Increasing doses of 1, 2.5, 6.25, 12.5 and 25 mg of CPT were given at 2-h intervals. Increased stroke volume index (SVI) and reduced mean pulmonary capillary wedge (PCW) pressure occurred at 1 h (P < 0.05) with an associated decline of blood pressure. Maximal hemodynamic improvement for the group was seen at 6 and 7 h following the 6.25 and 12.5 mg doses when SVI was elevated 35% and mean PCW pressure decreased 40% from control. CPT 12.5-50 mg every 8 h was continued long term in these 18 CHF patients. Four patients died, and 1 was noncompliant; drug therapy was withdrawn in 2 patients with symptomatic hypertension and in 1 patient who experienced an alteration in taste. The remaining 10 patients showed significant improvement in symptoms and treadmill exercise duration at 3 mo. after CPT therapy was started. Repeat hemodynamic measurements were similar to optimal measurements obtained during the initial study. In a further study, the acute hemodynamic and hormonal effects of sequentially randomized 5 mg prazosin and 25 mg CPT were compared in 10 CHF patients. While both drugs reduced PCW pressure and vascular resistance, CPT effects were greater. CPT alone effected a small rise in cardiac index and minor decline in heart rate, and CPT diminished aldosterone levels and increased plasma renin activity while prazosin did not.


PMID: 6291361

Other references

Schirren, C.G., 1963: Giant Vesicular Emphysema And Epidermoid Cancer. Revista Clinica Espanola 91: 252-253

Samii M.; Draf W., 1978: Neuro surgical ear nose throat treatment of lesions at the base of the skull. Acta Neurochirurgica 43(1/2): 117

Jarolimek, W.; Brunner, H.; Lewen, A.; Misgeld, U., 1996: Role of chloride-homeostasis in the inhibitory control of neuronal network oscillators. 1. Spontaneous synaptic activity in networks formed by dissociated neurons from embryonic rat midbrain was analyzed in tight seal whole cell recordings. 2. Application of furosemide (0.5 mM) to the cell and its surrounding area increased the frequ...

González, S.; Lobos, I.; Guajardo, A.; Celis, A.; Zemelman, R.; Smith, C.T.; Saglie, F.R., 1987: Yeasts in juvenile periodontitis. Preliminary observations by scanning electron microscopy. Through the use of the electron microscope, yeasts were found invading gingival connective tissue in juvenile periodontitis (JP). Samples (3-mm punch biopsies, including epithelium and underlying connective tissue) were taken apically to periodont...

Frei, S.Michaela.; Pesch, T.; Lang, S.; Weber, A.; Jehle, E.; Vavricka, S.R.; Fried, M.; Rogler, G.; Scharl, M., 2014: A role for tumor necrosis factor and bacterial antigens in the pathogenesis of Crohn's disease-associated fistulae. Intestinal fistulae represent a severe complication of Crohn's disease (CD). The authors have demonstrated that epithelial-to-mesenchymal transition plays a pivotal role in their pathogenesis. High levels of interleukin-13 and tumor necrosis...

Mukherjee, S.; Maxfield, F.R., 2004: Membrane domains. Considerable evidence shows that lateral inhomogeneities in lipid composition and physical properties exist in biological membranes. These membrane lipid domains are proposed to play important roles in processes such as signal transduction and mem...

Arling, L., 1966: Industrial clinics and occupational medicine. Archives of Environmental Health 12(5): 644-646

Fowler, J.F.; Whitsed, C.A.; Joiner, M.C., 1989: Repair kinetics in mouse lung: a fast component at 1.1 Gy per fraction. Four experiments to measure the half-time of repair of radiation damage in mouse lung are described. Three of these experiments used two or four doses per fraction of 3.6-9 Gy. Half-times of approximately 0.6 h were found. The fourth experiment in...

Lessard, J.C.; Piña-Paz, S.; Rotty, J.D.; Hickerson, R.P.; Kaspar, R.L.; Balmain, A.; Coulombe, P.A., 2014: Keratin 16 regulates innate immunity in response to epidermal barrier breach. Mutations in the type I keratin 16 (Krt16) and its partner type II keratin 6 (Krt6a, Krt6b) cause pachyonychia congenita (PC), a disorder typified by dystrophic nails, painful hyperkeratotic calluses in glabrous skin, and lesions involving other e...

Arcondéguy, T.; Jack, R.; Merrick, M., 2001: P(II) signal transduction proteins, pivotal players in microbial nitrogen control. The P(II) family of signal transduction proteins are among the most widely distributed signal proteins in the bacterial world. First identified in 1969 as a component of the glutamine synthetase regulatory apparatus, P(II) proteins have since been...