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Immuno histological study of the cell differentiation in human gastro intestinal cancers


, : Immuno histological study of the cell differentiation in human gastro intestinal cancers. Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 174(4): 756-766

Using immunofluorescence, well differentiated mucus cells which are specialized in the synthesis of M antigens were found in the normal adult gastrointestinal tract. Mucus cells of surface epithelium show M1 antigens, those of gastric and intestinal glands, respectively, M2 and M3 antigens. In the fetus, immature mucus cells contain 2 types of M antigens: M1M2 (stomach) or M1M3 (colon). Certain histological types of gastrointestinal adenocarcinomas and digestive precancerous lesions show such fetal type associations which appear as modifications of cell differentiation associated with malignant process.

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