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Immuno therapy of murine leukemia 2. effect of passive serum therapy on friend murine leukemia virus induced hematologic and coagulation parameters


, : Immuno therapy of murine leukemia 2. effect of passive serum therapy on friend murine leukemia virus induced hematologic and coagulation parameters. Journal of the National Cancer Institute 64(3): 547-554

Hematologic and coagulation parameters of DBA/2J mice infected with Friend murine leukemia virus (F-MuLV) were compared to those of mice protected against development of virus-induced disease by passive administration of chimpanzee anti-F-MuLV antiserum (CaF-MuLV), as well as to those of uninfected serum-treated controls. At 2 wk after F-MuLV inoculation, infected mice treated with normal chimpanzee serum (NCS) showed significant splenomegaly with mild leukocytosis and thrombocytopenia, but no difference was observed in prothrombin (PT) time or activated partial thromboplastin (APTT) time as compared to those of uninfected controls. Mice infected with F-MuLV but treated with CaF-MuLV had no splenomegaly or leukocytosis and demonstrated normal PT and APTT values, though moderate thrombocytopenia was evident. By 4 wk after infection, mice treated with NCS showed marked splenomegaly and leukocytosis accompanied by moderate anemia, while mice that received CaF-MuLV had only a mild leukocytosis. Neither group showed a significant difference in platelet count, PT or APTT values as compared to those of uninfected controls. F-MuLV-infected N:NIH(S) nude athymic mice given NCS showed significant mortality (70%) by 4 wk after inoculation, with survivors having marked splenomegaly, mild leukocytosis and thrombocytopenia but normal PT and APTT values. Virus-infected N:NIH(S) nude mice treated with CaF-MuLV had reduced mortality (20%), with survivors demonstrating mild splenomegaly and moderate thrombocytopenia but normal PT and APTT values. No qualitative difference in platelet function, as measured by ADP stimulation, were seen in infected mice treated with NCS or CaF-MuLV or in uninfected controls. The intrinsic and extrinsic clotting systems in the mouse apparently do not appear to be affected by F-MuLV-induced erythroleukemia, and the mild to moderate thrombocytopenia seen may not play a significant role in the pathobiology of this disease.

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PMID: 6928240


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