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Immuno therapy of murine leukemia 5. protection against friend leukemia virus induced complex glomerulo nephritis by passive serum therapy


, : Immuno therapy of murine leukemia 5. protection against friend leukemia virus induced complex glomerulo nephritis by passive serum therapy. Journal of the National Cancer Institute 67(3): 703-718

The development of immune complex glomerulonephritis in DBA/2 mice infected with Friend murine leukemia virus (F-MuLV) was compared with that in mice protected against virus-induced disease by administration of chimpanzee anti-F-MuLV antiserum (CaF-MuLV). Morphologic analysis of glomeruli from viremic (infected) normal chimpanzee serum-treated animals revealed significant renal disease within 2 wk following virus inoculation, with glomerular immune complex deposits and C-type viral particles seen by EM. Localization of F-MuLV envelope and core antigens (gp71 and p30, respectively) was also detected by immunofluorescence, as was murine IgG and C3. Age-matched DBA/2 mice treated with CaF-MuLV antiserum alone or following F-MuLV inoculation showed no evidence of systemic disease and neither localization of F-MuLV antigens nor detectable virus particles. In addition to erythroleukemia, F-MuLV infection results in severe immune complex glomerulonephritis and that passive immunotherapy can protect susceptible mice from both aspects of viral pathogenesis.

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