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Immunoglobulin m and immunoglobulin g antibodies to phenolic glycolipid i from mycobacterium leprae in leprosy insight into patient monitoring erythema nodosum leprosum and bacillary persistence


, : Immunoglobulin m and immunoglobulin g antibodies to phenolic glycolipid i from mycobacterium leprae in leprosy insight into patient monitoring erythema nodosum leprosum and bacillary persistence. Journal of Investigative Dermatology 86(5): 529-534

Serum IgM and IgG antibodies against Mycobacterium leprae-derived phenolic glycolipid I (PG) were determined in leprosy patients, contacts, and controls by enzyme-linked immunosorbent assay (ELISA). Anti-PG IgM levels increased from the tuberculoid (TT) to the lepromatous (LL) pole of the disease spectrum. There was a positive linear correlation between anti-PG IgM and bacillary index (BI). Patients with erythema nodosum leprosum (ENL) had lower levels of serum anti-PG IgM than non-ENL patients of comparable BI, suggesting that anti-PG IgM is involved in the pathogenesis of ENL. Initial observations indicate that high anti-PG IgM levels in bacillary-negative patients might reflect bacillary persistence. A study of 2 different substrate reagents in the ELISA [2,2'-azino-di(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), 0.1 mM H2O2, serum diluted 1:20, and o-phenylendiamine (OPD), 5 mM H2O2, serum diluted 1:300] showed generally good correlation in detection of anti-PG IgM. However the OPD system detected more paucibacillary disease (BT), while the ABTS system detected the significant effect of ENL on the relationship between BI and anti-PG IgM. Anti-PG IgM was clearly dominant over anti-PG IgG. However, certain patients, including several patients who had upgraded from LL and borderline lepromatous leprosy (BL), showed high levels of anti-PG IgG. Since studies have shown that LL patients are selectively deficient in cell-mediated immunity, T-cell products may be required for the IgM to IgG isotype switch. We conclude that anti-PG IgM is useful for monitoring the bacillary load in individual patients and should prove useful for leprosy control strategies.

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Other references

Quagliarini, F.; Carfagna, C.M.; Mattia, P.; Gervasio, C., 1994: Report of a case of aneurysm of the right branch of the portal vein examined with echo-color-Doppler. La Radiologia Medica 87(5): 713-714

Anonymous, 1981: Pressurised gasification of wood with oxygen combustion or electrical heating Methanol production. Energy from biomass: proceedings of the EC contractors' meeting held in Copenhagen 23-24 June 1981 edited by P Chartier and W Palz: 193

Bastian W.; Castells S.; Torrado C.; Yasumura S.; Smith S., 1989: Changes in plasma osteocalcin oc and somatomedin c sm c in growth hormone gh deficiency after intramuscular injection of hgh. Pediatric Research 25(4 PART 2): 80A

Olson, J.M.; Junck, L.; Young, A.B.; Penney, J.B.; Mancini, W.R., 1988: Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. Binding of the isoquinoline PK 11195 and of the benzodiazepines Ro5-4864 and flunitrazepam was compared in glioma cells and tissues. In human and rat glioma cell cultures [3H]PK 11195 bound with higher affinity (Kd = 14.01 and 15.76 nM, respective...

Kaymakcalan S.; Kayan S.; Ayhan I.H., 1970: The role of serotonin in morphine abstinence syndrome. Ankara Universitesi Tip Fakultesi Mecmuasi 23(1): 56-67

Igaz, I.; Nyírő, Gábor.; Nagy, Zán.; Butz, H.; Nagy, Z.; Perge, Pál.; Sahin, P.; Tóth, Mós.; Rácz, Károly.; Igaz, P.; Patócs, A., 2015: Analysis of Circulating MicroRNAs In Vivo following Administration of Dexamethasone and Adrenocorticotropin. Purpose. The interaction of hormones of the pituitary-adrenal axis and adrenal cortex-associated circulating microRNAs is mostly unknown. We have studied the effects of dexamethasone and adrenocorticotropin on the expression of five circulating mi...

Savage, K.J.; Harris, N.Lee.; Vose, J.M.; Ullrich, F.; Jaffe, E.S.; Connors, J.M.; Rimsza, L.; Pileri, S.A.; Chhanabhai, M.; Gascoyne, R.D.; Armitage, J.O.; Weisenburger, D.D.; Savage, K.; Connors, J.; Gascoyne, R.; Chhanabhai, M.; Wilson, W.; Jaffe, E.; Armitage, J.; Vose, J.; Weisenburger, D.; Anderson, J.; Ullrich, F.; Bast, M.; Hochberg, E.; Harris, N.; Levine, A.; Nathwani, B.; Miller, T.; Rimsza, L.; Montserrat, E.; Lopez-Guillermo, A.; Campo, E.; Cuadros, M.; Alvarez Ferreira, J.; Martine, 2008: ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project. The International Peripheral T-Cell Lymphoma Project is a collaborative effort designed to gain better understanding of peripheral T-cell and natural killer (NK)/T-cell lymphomas (PTCLs). A total of 22 institutions in North America, Europe, and As...

Narchi, H., 1998: Serum bicarbonate and dehydration severity in gastroenteritis. The concentration of bicarbonate was measured in serum samples from 106 children with gastroenteritis and dehydration. A concentration less than 22 mmol/l was more common in children with severe dehydration, but the magnitude of bicarbonate reduct...

Xu, Y.; Qian, C., 2013: Application of Gurson-Tvergaard-Needleman constitutive model to the tensile behavior of reinforcing bars with corrosion pits. Based on meso-damage mechanics and finite element analysis, the aim of this paper is to describe the feasibility of the Gurson-Tvergaard-Needleman (GTN) constitutive model in describing the tensile behavior of corroded reinforcing bars. The orthog...

Bjorkhaug, H., 2006: Is there a female principle in organic farming? An interpretation of data for Norway. This chapter explores whether female farmers in Norway represent different management values and attitudes to male farmers, or whether male and female organic farmers together represent a more feminine way of farming than conventional farmers do....