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Importance of the fibrinolytic system in pneumonia complicated by exudative pleurisy in children


, : Importance of the fibrinolytic system in pneumonia complicated by exudative pleurisy in children. Voprosy Meditsinskoi Khimii 34(2): 110-113

Phasic alterations in fibrinolytic activity were found in blood plasma of children with pneumonia complicated by exudative pleurisy. Hypercoagulation and inhibition of fibrinolytic activity were observed at the beginning of the disease. Hypercoagulation and an increase in the fibrinolytic activity occurred during restoration. In the children with lung destruction the fibrinolytic activity was increased in blood and in exudates before the appearance of roentgenologic indications of the destructive alterations. The fibrinolytic activity was inhibited in children with metapneumonic pleurisy formed during pneumonia and characterized by long-term and severe course. Role of fibrinolysis as possible pathogenetic factor responsible for development of complications is discussed.

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