geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

In vitro effects of angiotensin II on glomerular function


, : In vitro effects of angiotensin II on glomerular function. American Journal of Physiology 251(4 Pt 2): F627-F634

Effects of incubation with angiotensin II (ANG II) on isolated rat glomeruli were studied to test the hypothesis that ANG II exerts a direct effect on glomerular ultrafiltration coefficient (Kf) or hydraulic conductivity (Lp). Glomeruli of adult Munich-Wistar rats were isolated in isotonic medium and incubated at 37.degree. C in control medium or in medium containing ANG II (5.3 .times. 10-9 to 5.3 .times. 10-6 M) for 20 min. Glomerular volume decreased after incubation with ANG II. Relative volume decrement of unselected cortical glomeruli averaged 6 .+-. 3% in 5.3 .times. 10-9 or 10-8 M ANG II and 13 .+-. 3% in 5.3 .times. 10-6 M ANG II; volume of superficial cortical glomeruli and deep cortical gomeruli diminished by 9 .+-. 2 and 5 .+-. 0.5%, respectively, after incubation with ANG II 5.3 .times. 10-6 M. Glomerular oncometric response after equilibration with media of differing protein concentrations was not altered by ANG II incubation. Kf and Lp assessed in samples of glomeruli following ANG II incubation averaged 4.5 .+-. 0.5 nl .cntdot. mm-1 .cntdot. mmHg and 2.7 .+-. 0.5 .mu.l .cntdot. mm-1 mmHg .cntdot. cm2, respectively, and were not significantly different from control values (3.8 .+-. 0.3 nl .cntdot. mm-1 .cntdot. mmHg and 2.4 .+-. 0.3 .mu.l .cntdot. mm-1 .cntdot. mmHg .cntdot. cm2), respectively. In replicate studies of individual glomeruli prior to and after ANG II incubation, Kf was also not significantly altered (control Kf, 6.1 .+-. 1.1; Kf after ANG II, 4.4 .+-. 0.9 nl .cntdot. min-1 .cntdot. mmHg). We conclude that glomerular contraction caused by incubation with ANG II does not directly effect a change in glomerular Kf or Lp and that glomerular contraction and glomerular capillary hydraulic permeability are relatively independent properties. Decreased Kf in vivo after ANG II administration is most likely a result of altered intraglomerular perfusion patterns or of secondary changes in the capillary wall mediated by factors that are not operative in vitro.

US$29.90

PMID: 3766739


Other references

Schmelz, Gary W., 1995: Notes on the fauna of the Chipola Formation - 39. A new species of the genus Parametaria (Gastropoda: Columbellidae). Tulane Studies in Geology and Paleontology ember 15; 28(3-4): 116-118

Ducke, A., 1938: Die Gattungen Coumarouna Aubl und Taralea Aubl. A revision of the two South American genera. Coumarouna belongs in the Dalbergieae, Taralea in the Galegeae. von Schreber erred in uniting them into the genus Dipteryx. A new species is described in Coumarouna.

Illenberger, W.K., 1988: The dunes of the Alexandria coastal dunefield, Algoa Bay, South Africa. There is a large variety of dunes in the Alexandria coastal dunefield. The dominant dune type of the active (unvegetated) dunefield is an akle pattern. Transverse dunes form the major component of this pattern, and longtitudinal dunes the minor co...

Frankfurt; Miller; Strikman, 1993: Evidence for color fluctuations in hadrons from coherent nuclear diffraction. Physical Review Letters 71(18): 2859-2862

Connor, Jm, 1980: Competition in the U.S. food marketing system. This report is a survey of two broad topics relating to the U.S. food marketing system. First, it examines what is known about market structure and economic performance of the several stages of the system: food processing, food wholesaling, groce...

Matthews J.S.; Reynolds J.A.; Weesner D.E.; Perry J.L.; Jenkins A.L., 1983: Rapid speciation and biotyping of respiratory isolates of haemophilus. Abstracts of the Annual Meeting of the American Society for Microbiology 83: C264

Lanier, L.L.; Chang, C.; Spits, H.; Phillips, J.H., 1992: Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes. NK cells have been defined as CD3-, CD16+, and/or CD56+ lymphocytes that mediate MHC-unrestricted cytotoxicity against certain tumors and virus-infected cells. Although CD3.epsilon. transcripts have been detected in some NK clones, it has generall...

Rapp, W.; Strafuss, A., 1973: Ectopic ameloblastoma in a dog. journal of the American Animal Hospital Association: 9 (6) 582-584

Ruan, X.; Mancuso, K.F.; Kaye, A.David., 2016: Determination of the unbound fraction of R- and S-methadone in human brain. International Journal of Legal Medicine: -

Albrecht, R.; Haase, D.; Zippel, R.; Koch, H.; Settmacher, U., 2017: Robot-assisted surgery - Progress or expensive toy? : Matched-pair comparative analysis of robot-assisted cholecystectomy vs. laparoscopic cholecystectomy. By means of a matched-pair analysis comparing data obtained from laparoscopic cholecystectomy (LC) and robot-assisted laparoscopic cholecystectomy (RAC), the value of both methods as well as the advantages and disadvantages of both approaches wer...