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In vivo metabolism of 11 hydroxy delta 8 tetra hydro cannabinol to 2 carboxylic acids and the effects of skf 525 a cobaltous chloride and pheno barbital on their formation in rats

, : In vivo metabolism of 11 hydroxy delta 8 tetra hydro cannabinol to 2 carboxylic acids and the effects of skf 525 a cobaltous chloride and pheno barbital on their formation in rats. Chemical & Pharmaceutical Bulletin (Tokyo) 28(7): 2154-2157

Two carboxylic acids were isolated as the major metabolites from the liver of rats injected with 11-OH-.DELTA.8-tetrahydrocannabinol (11-OH-.DELTA.8-THC). A metabolite was identified as .DELTA.8-THC-11-oic acid and the other was assumed to be 7-OH-.DELTA.8-THC-11-oic acid. The effects of SKF 525-A [proadifen hydrochloride], cobaltous chloride and phenobarbital on the contents of these metabolites in the rat liver were studied. Pretreatment with SKF 525-A and cobaltous chloride caused decreases in the contents of these metabolites (by 73 and 70% for .DELTA.8-THC-11-oic acid, and by 91 and 89% for 7-OH-.DELTA.8-THC-11-oic acid, respectively). The level of 7-OH-.DELTA.8-THC-11-oic acid was increased, but that of .DELTA.8-THC-11-oic acid remained unchanged by pretreatment with phenobarbital. The metabolism of 11-OH-.DELTA.8-THC to .DELTA.8-THC-11-oic acid and 7-OH-.DELTA.8-THC-11-oic acid is mediated in part by the microsomal monooxygenase system in vivo.


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