geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India


, : Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India. Journal of Medical Genetics 24(6): 362-365

Consanguineous marriages are strongly favoured among the populations of South India. In a study conducted on 407 infants and children, a total of 35 genetic diseases was diagnosed in 63 persons: 44 with single gene defects, 12 with polygenic disorders, and seven with Down's syndrome. The coefficient of inbreeding of the total study group, F = 0.0414, was significantly higher than that previously calculated for the general population, F = 0.0271, and autosomal recessive disorders formed the largest single disease category diagnosed. The results suggest that long term inbreeding may not have resulted in appreciable elimination of recessive lethals and sub-lethals from the gene pool.

US$19.90

PMID: 3612707

DOI: 10.1136/jmg.24.6.362


Other references

Saletta, F.J.; Rukstinat, G.J., 1953: Unusual postoperative ventral hernia. Illinois Medical Journal 103(1): 50-52

Anonymous, 1990: Appendix. Chlamydial infections in men. Primary Care 17(1): 205-206

Hoffrage, U.; Gigerenzer, G.; Krauss, S.; Martignon, L., 2002: Representation facilitates reasoning: What natural frequencies are and what they are not. A good representation can be crucial for finding the solution to a problem. Gigerenzer and Hoffrage (Psychol. Rev. 102 (1995) 684; Psychol. Rev. 106 (1999) 425) have shown that representations in terms of natural frequencies, rather than condition...

Brandl, R.; Stiegler, H., 2007: Therapieresistente Wunden der unterein Extremitat. DMW Deutsche Medizinische Wochenschrift 132(20): 1103-1116

Allain P.; Mauras Y.; Tafforeau C.; Houssin A.; Cartier F., 1984: Changes in plasma and erythrocyte rubidium concentrations in patients with renal failure. Rb concentrations were measured by flame emission spectrophotometry in whole blood, plasma and red cells from male and female controls and from dialyzed and non-dialyzed patients of both sexes with chronic renal failure. Rb concentrations (.mu.mol...

Gorbunova, I.M.; Zalkind, V.I., 1977: Characteristics of adaptation of muscle stretch receptors of the dynamic type. In cats with de-efferented m. [musculus] triceps, some stretch receptors of the dynamic type adapted rapidly after stretching of the muscle and keeping it at the new length; other receptors revealed rapid and slow adaptation components. Units with...

Badger, S.B., 1982: Infectious epiphysitis and valvular endocarditis in a red deer (Cervus elaphus). A 10-month-old male red deer was presented with severe lameness and enlargement of the fetlock areas of both front and one hind legs. Radiographs demonstrated an epiphysitis and osteomyelitis of the distal metacarpal and metatarsal bones. PM exami...

Klapper, B.; Schirlo, C., 2016: Special edition booklet: Interprofessional Training - Published by the Robert Bosch Stiftung and the Gesellschaft für Medizinische Ausbildung. Gms Journal for Medical Education 33(2): Doc38-Doc38

Nijs, M.; Franssen, K.; Cox, A.; Wissmann, D.; Ruis, H.; Ombelet, W., 2008: Reprotoxicity of intrauterine insemination and in vitro fertilization-embryo transfer disposables and products: a 4-year survey. To test consumables and other products used during oocyte collection, sperm preparation, IUI, embryo culture, and IVF-embryo transfer for their possible reprotoxic properties. A prospective 4-year survey of reprotoxicity testing of consumables and...

Seewald, K.; Debrunner, A.M., 1966: Changes in the homolateral knee joint in patients with hip ankylosis. Zeitschrift für Orthopadie und Ihre Grenzgebiete 102(2): 270-285