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Induction of mutation by gamma irradiation in the presence of oxygen or nitrogen

, : Induction of mutation by gamma irradiation in the presence of oxygen or nitrogen. Texas Journal of Science 31(5 SUPPL): 73-84

A strain of Aspergillus nidulans was used to study the inactivation and mutagenic effect of 60Co .gamma.-rays in the presence of O and N. Mutation induction was studied by the methionine system, which detects simultaneoulsy forward mutation at a number of gene loci (at least 6). The existence was demonstrated of a marked differential forward mutational response of gene loci in Aspergillus conidia that is dependent upon whether .gamma.-irradiation in aqueous solution was carried out in the presence of O or N. This effect is independent of the dose of radiation exposure. The specificity for mutation is altered by the presence of the self-inhibitor of germination for the anoxic treatment, but not for the oxic irradiation. The implications of different OER (oxygen enhancement ratios) for mutation induction in different classes or genes for the mechanisms and type of damage induced by the 2 radiation conditions are discussed.


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