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Influence of dl methionine on the photostability of ascorbic acid solutions

, : Influence of dl methionine on the photostability of ascorbic acid solutions. Drug Development & Industrial Pharmacy 11(12): 2109-2126

The photostabilizing effect of DL-methionine for various buffered solutions of ascorbic acid was investigated. DL-methionine in a concentration of 10 mg% was found to enhance the photostability of 40 mg% ascorbic acid in acetate and phosphate buffers, but not in citrate buffer of pH 4.5. The photoprotective action of DL-methionine appeared to be influenced by its concentration, the pH of the medium and its buffer species. DL-methionine was also found to demonstrate its photoprotective action in presence of glycerin, EDTA and Tween 80. PEG 300, however, appeared to have a detrimental effect on the photostabilizing action of DL-methionine for ascorbic acid in acetate buffer of pH 4.5.


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