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Influence of yohimbine on release of anterior pituitary hormones

, : Influence of yohimbine on release of anterior pituitary hormones. Life Sciences 39(5): 395-398

We used a double-blind crossover design to study the effects of .alpha.2 adrenoreceptor blockade with yohimbine on levels of anterior pituitary hormones. A dose of yohimbine was used which raised plasma norepinephrine from 379 .+-. 74 (S.E.) to 730 .+-. 143 pg/ml and mean arterial pressure from 83 .+-. 4 to 92 .+-. 5 torr (p < 0.025). This dose (125 .mu.g/kg, then 1 .mu.g/kg/min) also altered mood when compared to saline infusion. In spite of these changes, when prolactin, cortisol, ACTH, .beta.-endorphin, TSH and growth hormone were measured after 45 minutes of yohimbine infusion, no changes from baseline were noted. These data suggest that in normal man, at rest, .alpha.2 adrenoreceptors in the hypothalamus, adenohypophysis or other brain areas do not tonically modulate release of these hormones into the blood.


PMID: 3016439

DOI: 10.1016/0024-3205(86)90518-7

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