+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Influences of sinusoidal electric fields on excitability in the rat hippocampal slice

, : Influences of sinusoidal electric fields on excitability in the rat hippocampal slice. Brain Research 323(2): 227-238

The influence of extracellular sinusoidal electric fields on the amplitude of population spikes evoked by single test pulses in excitatory pathways to CA1 pyramidal neurons was studied in rat hippocampal slices. The fields in the tissue were of the order of EEG gradients. Stimulation at 5 Hz, a frequency represntative of hippocampal activity, was compared with 60 Hz, which is often used in kindling procedures. Brief stimulation (5-30 s) with both 5 and 60 Hz fields (20-70 mV/cmp-p in the perfusing solution) often produced a long-term increase (> 10 min) of the population spike. Fields at 60 Hz, but not at 5 Hz, also induced short-term depression (1-6 min) or transient post-field excitation (15-30 s). Prolonged stimulation (3 min) emphasized this frequency dependent response: fields at 5 Hz induced long-lasting potentiation while fields at 60 Hz always resulted in progressive depression persisting for a few minutes after the end of stimulation. These effects appeared as a global response of CA1 neurons. Antidromic responses studied during blockade of synaptic transmission (0.2 mM Ca2+, 4 mM Mg2+) were depressed during and following 3 min field stimulation at either frequency, which could reflect failing Ca mechanisms in the tissue. The field influence on the potential evoked by synaptic or antidromic stimulation was independent of the phase of the sine wave at which the test pulse was delivered, arguing against a direct polarization of the cell membrane by the fields. The experimental evidence suggests a functional role for EEG-like fields in hippocampal excitability.


PMID: 6098340

DOI: 10.1016/0006-8993(84)90293-2

Other references

Gangemi, M.; Renier, D.; Daussange, J.; Hirsch, J.F.; Rigault, P., 1982: Children's cervical spine instability after posterior fossa surgery. Cervical spine stability of 98 children operated on the posterior fossa was studied: 14 of them had an instability. The main factor in these instabilities was the number of levels at which the laminectomy associated with the occipital craniectomy...

Rashid, G.; Korzets, Z.; Sayag, D.; Aricha, Z.; Bernheim, J., 2001: Advanced glycation end products modified beta2-microglobulin stimulate TNF-alpha and IL1-beta production by human peritoneal macrophages. Nephrology Dialysis Transplantation 16(6): A19, June

Babaiants, A.A.; Diuĭsalieva, R.G.; Marchenko, V.I., 1970: The mechanism of stimulation of interferon formation in cells preliminarily treated with interferon. Voprosy Virusologii 15(4): 432-435

Briese, T.; de la Torre, J.C.; Lewis, A.; Ludwig, H.; Lipkin, W.I., 1992: Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells. Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Bor...

Bott, R.; Saldajeno, M.; Cuevas, W.; Ward, D.; Scheffers, M.; Aehle, W.; Karkehabadi, S.; Sandgren, M.; Hansson, H., 2008: Three-dimensional structure of an intact glycoside hydrolase family 15 glucoamylase from Hypocrea jecorina. The three-dimensional structure of a complete Hypocrea jecorina glucoamylase has been determined at 1.8 A resolution. The presented structure model includes the catalytic and starch binding domains and traces the course of the 37-residue linker s...

Naar, Z.; Dobos, A., 2006: Redundancy analysis of the influence of metal content and other edaphic parameters on the co-exsistence of Trichoderma species. The growth requirements of Trichoderma fungi that are wide spread saprotrophic soil microorganisms, are quite similar, therefore it is essential to define the environmental factor(s) along which they divide the available ecological niches. For th...

Martinez, A.T.; Martinez, M.J.; Almendros, G., 1986: Extracellular (1- >3),(1- >6)-linked b- D-glucan produced by the soil fungus Ulocladium atrum. Soil Biology and Biochemistry 18(5 ): 9-74

Zombre, P.N., 2006: Changes in the biological activity of zipella (bare soils) in the subsahelian zone of Burkina Faso and impact of the technique of zai. This study focused on the two types of bare soils (zipella) collected from the north-centre of Burkina Faso, viz., a lixivied ferruginous soil and an eutrophic brown soil. The biological activity was evaluated in relation to soil surface character...

Takahashi, N.; Toda, H.; Nishibe, H.; Yamamoto, K., 1982: Isolation and characterization of Taka-amylase A apoprotein deglycosylated by digestion with almond glycopeptidase immobilized on Sepharose. Taka-amylase A (1,4-alpha-D-glucan glucanohydrolase, EC, which contains a single asparagine-linked oligosaccharide unit, was digested with almond glycopeptidase immobilized on Sepharose 6B at 20 degrees C for 4 h. A maximum of 10% of the...

Demant, P., 1976: Mouse membrane alloantigen news. H-2 registry bulletin No. 12. Brief reports are given of haplotype symbols, 3 new recombinant haplotypes in the progeny of H-2t1/H-2b heterozygotes, H-2.22 (a newly described private specificity of H-2Dp), Ia.23 (probably the private specificity of I-Ed), and the H-2L locus.