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Inhibition of cholera toxin induced intestinal hyper secretion by neuroleptics


, : Inhibition of cholera toxin induced intestinal hyper secretion by neuroleptics. Acta Pharmacologica et Toxicologica 50(4): 294-299

Various types of neuroleptics and other agents were examined for inhibitory effect in cholera toxin-induced hypersecretion in ligated loops of mice jejunum. Several agents belonging to the phenothiazine group or thioxanthene group were inhibitory. Only 3 other neuroleptics, loxapin, haloperidol and penfluridol, inhibited the hypersecretion. Among the miscellaneous agents, Ca antagonist nifedipine was inhibitory. The potencies of the neuroleptics did not correlate with the dopamine antagonistic potencies. Evidently, the site of antisecretory action of the drugs lies outside the CNS.

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