+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Inhibition of leukotriene C and leukotriene D biosynthesis

, : Inhibition of leukotriene C and leukotriene D biosynthesis. Journal of Biological Chemistry 255(17): 8023-8026

Leukotriene C4, and leukotriene D4 are slow reacting substances [of anaphylaxis] produced by mouse mastocytoma [CXBGABMCT-1] cells and rat basophilic leukemia [RBL-1] cells, respectively. Serine.cntdot.borate complex, an inhibitor of glutamyl transpeptidase (EC, prevented the formation of the biologically more potent leukotriene D4 and caused accumulation of leukotriene C4 in rat basophilic leukemia cell suspensions. 5,8,11-Eicosatrienoic acid, a lipoxygenase inhibitor, prevented the biosynthesis of leukotriene C4 (ID50, 5 .mu.M) by mastocytoma cells. .gamma.-Glutamyl transpeptidase apparently is involved in the biosynthesis of leukotriene D4; leukotriene C4 probably is formed as an intermediate.


PMID: 6106018

Other references

Sada, M.; Saraya, T.; Tanaka, Y.; Sato, S.; Wakayama, M.; Shibuya, K.; Uchiyama, T.; Ogata, H.; Takizawa, H.; Goto, H., 2014: Invasive tracheobronchial aspergillosis in a patient with systemic lupus erythematosus-dermatomyositis overlap syndrome. A 45-year-old man was referred to our hospital with a 3-month history of dyspnea, polyarthralgia, myalgia and weight loss. He was diagnosed with systemic lupus erythematosus/dermatomyositis overlap syndrome with lung involvement, which presented a...

McNaughton Collins, M.; Stafford, R.S.; Barry, M.J., 2000: Age-specific patterns of prostate-specific antigen testing among primary care physician visits. Early detection of prostate cancer is thought to be effective, and indirect evidence suggests that men aged 50 to 69 years will benefit most while those aged 70 and older will benefit least from it. The goal of our study was to describe usual care...

Wayal, S.; Llewellyn, C.; Smith, H.; Fisher, M., 2011: Home sampling kits for sexually transmitted infections: preferences and concerns of men who have sex with men. The increasing prevalence of sexually transmitted infection (STI) and delays in access to sexual health care among men who have sex with men are a major public health concern in the UK. This qualitative study, involving semi-structured interviews...

Rejmankova, E., 1976: Germination of seeds of lemna gibba. The germination rate of L. gibba L. seeds was assessed at different water temperatures (17, 25 and C); under the influence of different storage conditions prior to germination (room temperature, C; refrigerator, C;..., J.; Gabersek, V.; Maton, P., 1972: Effect of arteriography on vestibular responses. Annales D'oto-Laryngologie et de Chirurgie Cervico Faciale 89(7): 397-403

Nauck, E.G., 1950: New research on the development of malaria parasites. Revista Medica de Costa Rica 17(192): 84-90

Lillie, R.S., 1914: Antagonism between salts and anesthetics IV Inactivation of salt solutions and hypertonic sea-water by anesthetics. Journal of Experimental Zoology Philadelphia, 16 591-616

Oustamanolakis, P.; Koutroubakis, I.E.; Messaritakis, I.; Kefalogiannis, G.; Niniraki, M.; Kouroumalis, E.A., 2012: Measurement of reticulocyte and red blood cell indices in the evaluation of anemia in inflammatory bowel disease. The commonest types of anemia in inflammatory bowel disease (IBD) are iron deficiency (IDA) and anemia of chronic disease. The differentiation between these two conditions is important for the management of the patient. The aim of this study was t...

Kim, S.-Oog; Orii, Y.; Lloyd, D.; Hughes, M., N.; Poole, R., K., 1999: Anoxic function for the Escherichia coli flavohaemoglobin (Hmp): Reversible binding of nitric oxide and reduction to nitrous oxide. The flavohaemoglobin Hmp of Escherichia coli is inducible by nitric oxide (NO) and provides protection both aerobically and anaerobically from inhibition of growth by NO and agents that cause nitrosative stress. Here we report rapid kinetic studie...

Adams-Chapman, I., 2006: Neurodevelopmental outcome of the late preterm infant. There is very limited information about the developmental outcome of the late preterm infant. The developing brain is vulnerable to injury during this very active and important stage of fetal brain development; therefore, it is important to carefu...