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Interaction between chlorhexidine digluconate and sodium monofluorophosphate in vitro

, : Interaction between chlorhexidine digluconate and sodium monofluorophosphate in vitro. Scandinavian Journal of Dental Research 96(1): 30-33

The aim of the present study was to investigte the compatibility of chlorhexidine digluconate and sodium monofluorophosphate since these agents are potential ingredients in future products in preventive dentistry. Varying combinations of chlorhexidine digluconate and sodium monofluorophosphate in water, covering the possible ranges of clinically relevant concentrations of both compounds, were made, incubated for 24 h and observed for precipitation of insoluble salts. The mixtures were analyzed for presence of free chlorhexidine and monofluorophosphate after incubation. The results showed that chlorhexidine digluconate and sodium monofluorophosphate are not compatible in clinically relevant concentrations. A chlorhexidine-monofluorophosphate salt of low solubility in water is presumably formed.


PMID: 3422503

DOI: 10.1111/j.1600-0722.1988.tb01404.x

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