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Inverse relationship of blood alcohol levels to energy availability in chronic alcoholic rats


, : Inverse relationship of blood alcohol levels to energy availability in chronic alcoholic rats. Biochemical Archives 4(1): 1-6

When Sprague Dawley rats were maintained ad libitum on various liquid diets containing 36%, 30% or 26% of energy from ethanol, they consumed daily about 1.4 g or 10 kcal of alcohol/100 g body weight. However, their blood alcohol levels (BAL) were high (200-300 mg/dl) when they obtained daily 18.3 or less kcals/100 g body weight from dietary components excluding alcohol. The BAL were markedly reduced (110 mg/dl) when the daily energy intake from dietary ingredients other than alcohol was increased from 18.3 kcals/100 g body weight by feeding 30% or 26% alcohol diets prepared by including additional amounts of protein or carbohydrate. Since many extrahepatic effects of chronic alcohol ingestion are attributed to high BAL, it would appear that they can be attenuated by a concomitant increased energy intake by the animal.

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