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Investigation of spermicidal activity of organic and nonorganic substances


, : Investigation of spermicidal activity of organic and nonorganic substances. Srpski Arkhiv za Tselokupno Lekarstvo 112(6): 673-679

A comparative study was made in vitro of spermicidal activity of superficially active substances, of organic and nonorganic substances which are usually combined with local contraceptive preparations. Spermicidity was determined according to a modified I.P.P.F. [International Planned Parenthood Foundation] test. The strongest spermicidal activity was registered in non-ion superficially active nonoxinol-9. The 1:18,000 solution of this substance completely immobilized human spermatozoa in 20 s. Cation active benzalkonium-chloride was spermicidal only in a 1:1500 solution, and anion active substance sodium natrium laurilsulfate in a 1:1500 solution. The spermicidal activity of acids depended on anion hydrogen concentration and of the nature of anion. Milk acid was spermicidal in a 1:5000 solution, while borate acid was not spermicidally active. Concentration of methyl and propyl hydroxybenzoates used in the prevention of microorganism growth did not immobilize human spermatozoa.

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