+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ixodes dammini induced skin lesions in guinea pigs and rabbits compared to erythema chronicum migrans in patients with lyme arthritis

, : Ixodes dammini induced skin lesions in guinea pigs and rabbits compared to erythema chronicum migrans in patients with lyme arthritis. Experimental Parasitology 53(3): 381-395

Erythematous skin lesions occurred in rabbits 2 days after being fed upon by larvae or nymphs of the tick, Ixodes dammini. Similar lesions occurred in guinea pigs 7 days after a primary infestation with either larvae or nymphs. Host resistance to secondary feeding by larvae was demonstrated in guinea pigs and rabbits. Host resistance to secondary feeding by nymphs was seen in guinea pigs, but not in rabbits. Guinea pigs developed resistance to nymphs after being previously fed upon twice by larvae. All skin lesions in resistant guinea pigs contained large accumulations of basophils (49-76% of cells) with smaller (20-33%), but significant, numbers of eosinophils. These responses were characteristic of strong cutaneous basophil hypersensitivity reactions. Primary and secondary lesions in rabbits fed upon by larvae contained mostly mononuclear cells (46-52%) and moderate numbers (16-30%) of basophils and eosinophils. Primary and secondary lesions in rabbits fed upon by nymphs had few (3-11%) basophils and eosinophils and were dominated by mononuclear cells (73-86%). Acquired resistance in guinea pigs and rabbits was associated with cutaneous basophil and eosinophil responses and the lack of resistance of rabbits to nymphs was associated with erythematous lesions dominated by mononuclear cells. The mononuclear nature of rabbit lesions induced by nymphal feeding was similar to that seen in erythema chronicum migrans in Lyme arthritis patients who may be fed upon by I. dammini nymphs. the cutaneous basophil hypersensitivity characteristics of lesions in guinea pigs resistant to ticks was confirmed; a relationship between the mononuclear cell response of rabbits to nymphal I. dammini and the cellular response seen in patients with erythema chronicum migrans and Lyme arthritis.


PMID: 7084401

DOI: 10.1016/0014-4894(82)90081-9

Other references

Addison, R., 2000: Changing a suprapubic catheter--2. Nursing Times 95(43): Suppl 1-2

Breau, M.A.; Wilson, D.; Wilkinson, D.G.; Xu, Q., 2012: Chemokine and Fgf signalling act as opposing guidance cues in formation of the lateral line primordium. The directional migration of many cell populations occurs as a coherent group. An amenable model is provided by the posterior lateral line in zebrafish, which is formed by a cohesive primordium that migrates from head to tail and deposits future n...

Liu, Y.; Zhao, Y.; Luo, H.; Liu, F.; Wu, Y., 2017: Construction of EGFR peptide gefitinib/quantum dots long circulating polymeric liposomes for treatment and detection of nasopharyngeal carcinoma. Gefitinib/Quantum dots (QDs) loaded peptide long circulating liposomes (G/QDs-P-LCPL) were successfully prepared for treatment and detection by fluorescence labeling for nasopharyngeal carcinoma. Gefitinib was found to have marked inhibition which...

Schnitzer, M.;, W.A., 1952: A note on the podsolization process. A preliminary account of experiments on the effects of natural leachates from forest litter on the podzolic translocation of sesquihydroxides. The natural leachates or aqueous solutions from deciduous leaves or coniferous needles (called extracts)...

Jain, J.Kumar.; Prakash, M.S.; Mishra, R.K.; Khandhar, A.P., 2008: Simultaneous determination of multi drug components Theophylline, Etofylline, Guaiphenesine and Ambroxol Hydrochloride by validated RP-HPLC method in liquid dosage form. The RP-HPLC (reverse phase high performance liquid chromatography) method was developed and validated for simultaneous determination of Multi drug components i.e., Theophylline, Etofylline, Guaiphenesine and Ambroxol Hydrochloride in a liquid dosa...

Hammar S.L., 1988: Computer assisted detection evaluation and referral of sexually abused adolescents. Journal Of Adolescent Health Care: 260

Garrido, G.-F.V.ta, A., A., 1977: Effect of soil preparation on the mortality and growth of the Tasmanian bluegum (Eucalyptus globulus Labill). Boletin tecnico Universidad de Chile Facultad de Ciencias Forestales: 77, 45

Mazzocchi, G.; Nussdorfer, G.G., 1986: Chronic angiotensin treatment stimulates the growth and the 11 beta-hydroxylase activity of rat zona fasciculata cells. Long-term angiotensin-II (AII) administration provokes a time-dependent rise in the volume of zona fasciculata cells and in the plasma concentration of corticosterone in rats treated with dexamethasone and maintenance doses of ACTH. The AII-induce...

Iriuchishima, H.; Ozaki, S.; Konishi, J.; Matsumoto, M.; Murayama, K.; Nakamura, F.; Yamamoto, G.; Handa, H.; Saitoh, T.; Nagura, E.; Shimizu, K.; Nojima, Y.; Murakami, H., 2016: Primary Plasma Cell Leukemia in the Era of Novel Agents: A Multicenter Study of the Japanese Society of Myeloma. We investigated the treatment and outcome of Japanese patients with primary plasma cell leukemia (pPCL) in the era of novel agents and analyzed the risk factors affecting survival. Among 3,318 patients with symptomatic multiple myeloma (MM), 38 pa...

Fischer, J-C.; Serrette, D., 1985: Tertiaire-Quaternaire, Pliocene-Pleistocene. Dicerorhinus etruscus. Monde and Mineraux, 2pp. No. 69