geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Kupffer cell complement receptor clearance function after surgical injury and phagocytosis of immune complexes: effect of changes in plasma fibronectin


, : Kupffer cell complement receptor clearance function after surgical injury and phagocytosis of immune complexes: effect of changes in plasma fibronectin. Journal of Laboratory and Clinical Medicine 111(5): 504-510

The present study evaluated the effect of changes in plasma fibronectin levels on the degree of depression of in vivo clearance function of Kupffer cell complement receptors after injury and the phagocytosis of immune complexes. In vitro studies have suggested that fibronectin may act as an opsonin for the clearance of immune complexes from the blood by binding to C1q and may influence the expression and activation of immune receptors on macrophages. Complement receptor clearance function was assessed in rats from the hepatic uptake of rat erythrocytes coated with antierythrocyte IgM. Increasing plasma fibronectin by the injection of purified fibronectin or decreasing fibronectin by the injection of gelatin had no effect on complement receptor function in otherwise normal animals. Surgical injury depressed both plasma fibronectin levels and complement receptor function. Injection of fibronectin at the time of injury prevented the depression of receptor function; however, when fibronectin was given 1 hour after injury, receptor function remained depressed even though fibronectin levels were increased. The phagocytosis of immune complexes (IgG-coated rat erythrocytes [ElgGs]) depressed complement receptor function but did not depress plasma fibronectin levels. The depression of receptor function caused by the phagocytosis of ElgGs was prevented by administering fibronectin and was potentiated by administering gelatin, which decreased plasma fibronectin levels. Therefore, plasma fibronectin concentrations can influence in vivo Kupffer cell complement receptor function under certain conditions that lead to the depression of complement receptor function.

US$29.90

PMID: 3361229


Other references

Gulati, A.; Rajkumar, S.; Karthigeyan, S.; Sud, R.K.; Vijayan, D.; Thomas, J.; Rajkumar, R.; Das, S.C.; Tamuly, P.; Hazarika, M.; Ahuja, P.S., 2009: Catechin and catechin fractions as biochemical markers to study the diversity of Indian tea (Camellia sinensis (L.) O. Kuntze) germplasm. The heterogeneous Indian tea germplasm includes 'China', 'Assam', 'Cambod', and their hybrids which were evaluated using biochemical markers viz., total catechin and their fractions, for varietal identification and ch...

Cowden, J.W.; Copeland, R.A.; Schneider, M.S., 1989: Large diameter therapeutic penetrating keratoplasties. Fourteen penetrating keratoplasties were done on ten patients using 9.5 mm or larger diameter grafts. The causes for large grafts were perforation or impending perforation of large descemetoceles due to bacterial ulceration in five eyes, herpes si...

Wesolowski, Marian, 2006: Fenologia owocowania niektorych gatunkow chwastow w zasiewach wybranych roslin uprawnych. In the paper, the percentage shares of the phases of fruiting and diaspore shedding of some weed species during fodder beet, spring wheat and faba bean harvest are presented. The results of the study were gathered in the years 2000-2003 on river...

Anonymous, 1990: TBT anti-fouling paints. This supplemental training materials manual compiled by North Carolina contains overview and regulatory information and various publications including the EPA pesticide fact sheet number 143 on properties, uses, technology, toxic and environmental...

Collier, G.H., 1982: Determinants of choice. Nebraska Symposium on Motivation. Nebraska Symposium on Motivation 29: 69-127

Katakura, K., 1999: Molecular biology of drug resistance in Leishmania: gene amplification and P-glycoproteins. Drug resistance in Leishmania is reviewed under the following headings: gene amplification in drug-resistant Leishmania; P-glycoprotein gene family and multidrug resistance in Leishmania; possible mechanisms of resistance to pentavalent antimonial...

Van Wave, T.W.; Decker, M., 2003: Secondary analysis of a marketing research database reveals patterns in dairy product purchases over time. A method that uses marketing research data to analyze food purchase behavior and consequent nutrient availability was tested. Data relating to household food purchases accrued over a 13-week period were selected using universal product code number...

Cavallo T.; Granholm N.A., 1990: Repeated exposure to bacterial lipopolysaccharide interferes with disposal of pathogenic immune complexes in mice. Patients with systemic lupus erythematosus (SLE) experience clinical flares in association with superimposed bacterial infection. To investigate whether heightened immune phenomena during the course of bacterial infections were related to abnormal...

Jones G., 1985: Product patentability no longer uncertain. Practical Biotechnology 6(12): 4

Huang Ping, Zhou Jingfeng, 1995: Development of a planning and management model for pollutant discharge into a tidal river. Based on a differential river water quality model, a planning and management model for pollutants discharge into a tidal river has been derived, which described the relationship between a permissible discharge from each of all outfalls along the r...