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Lack of interaction of circulating thymus derived cells with phyto hem agglutinin in bacillary positive untreated lepromatous leprosy patients identification of sub population of lymphocytes by shifts in electrophoretic mobility


, : Lack of interaction of circulating thymus derived cells with phyto hem agglutinin in bacillary positive untreated lepromatous leprosy patients identification of sub population of lymphocytes by shifts in electrophoretic mobility. Journal of Immunology 118(1): 242-247

Incubation of human peripheral blood lymphocytes from normal healthy subjects with phytohemagglutinin (PHA), causes the reduction of the surface charge of a subpopulation of T [thymus-derived] cells by 1363 .+-. 242 e.s.u.[electrostatic unit]/cm2. The affected subpopulation was predominantly the high charge-bearing cells identifiable with early (10 min) rosette-forming cells with sheep erythrocytes. Purified lymphocytes obtained from untreated bacillary-positive, lepromatous leprosy patients contained high charge-bearing T lymphocyte subpopulation. Incubation with PHA did not result in the shift of electrophoretic mobility of these cells, suggesting the absence of interacting sites for the mitogen on the surface of these cells. The absence of mitogen-interacting sites is not an inherent trait of leprosy patients; the surface charge of lymphocytes from Dapsone-treated bacillary-negative subjects was reduced upon incubation with PHA. A close correlation was found between the number of cells whose charge alters on incubation with PHA and the transformation index obtained with this mitogen.

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