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Lack of interferon induction in man by two rabies tissue culture vaccines

, : Lack of interferon induction in man by two rabies tissue culture vaccines. Southeast Asian Journal of Tropical Medicine and Public Health 16(4): 521-524

Both neutralising antibody and interferon play a part in protection of animals against death from rabies virus infection. Interferon induction was therefore sought in 53 volunteers within 24 hours of receiving human diploid cell strain vaccine or fetal bovine kidney cell vaccine given either intramuscularly or intradermally. Repeat observations were made in 18 subjects following a second dose of vaccine seven days later. No interferon was detected in any sample tested although no subject had any detectable rabies neutralising antibody on day 0. The sensitivity of the interferon assay, and comparison with other studies are discussed. An interferon inducer suitable for human use should be sought as an alternative to, or a replacement for, passive rabies immunization.


PMID: 2424101

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Blanco-Ayala, T.; Andérica-Romero, A.C.; Pedraza-Chaverri, J., 2015: New insights into antioxidant strategies against paraquat toxicity. Paraquat (PQ, 1,1'-dimethyl-4-4'-bipyridinium dichloride) is a highly toxic quaternary ammonium herbicide widely used in agriculture, it exerts its toxic effects mainly because of its redox cycle through the production of superoxide anio...

Williams W.J., 1969: Transfer characteristics of 2 tandem nerve bundles. Jacobs, J E (Chairman) Proceedings Of The 8th International Conference on Medical And Biological Engineering And The 22nd Annual Conference on Engineering in Medicine And Biology (Including The 4th Annual Meeting Of Aami) Xxiii + 423p Illus The Conference Committee For The 8th Icmbe And 22nd Acemb (Including The 4th Annual Meeting Of Aami: Chicago, Ill , U S A ) 27-7

Blaney, H.F.; Criddle, W.D., 1962: Determining consumptive use & irrigation water requirements. Estimated seasonal consumptive use of water can be computed from the formula: U = KF where U is use of water in inches; K is an empirical seasonal consumptive-use coefficient depending on the crop (a list for important crops is given); & F is the...

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Fesus, L., 1992: Apoptosis and carcinogenesis. Chronica Dermatologica 2(3): 442-443

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Grassle J.Frederick, 1982: The biology of hydrothermal vents; a short summary of recent findings. Marine Technology Society Journal 16(3, Special issue, Polymetallic sulfides): 33-38

Leont'eva, N.S.; Meshalkin, I.N.; Ovchininskiĭ, N.N., 1970: Complications of gastric surgery in elderly patients. Khirurgiia 46(6): 46-50

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