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Lack of keratan sulfate in the human notochord


, : Lack of keratan sulfate in the human notochord. Journal of Anatomy 157: 175-179

Intervertebral discs, formed from notochord cell expansions during embryogenesis, are known to contain proteoglycans bearing keratan sulphate chains. Keratan sulphate has previously been demonstrated in Xenopus and chick notochords and in human fetal cartilage. In contrast, we have been unable to demonstrate keratan sulphate in human fetal notochord using two monoclonal antibodies, MZ15 and 5-D-4. The contribution made by notochoral-derived keratan sulphate to the glycosaminoglycan content of the mature invertebral disc may differ in man from that of other animal species.

US$29.90

PMID: 2974024


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