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Lack of linkage between genes controlling the synthesis of the complement c 7 and the hl a region on chromosome no 6 in man


, : Lack of linkage between genes controlling the synthesis of the complement c 7 and the hl a region on chromosome no 6 in man. Human Genetics 34(2): 137-142

The family of an individual was studied who lacks the 7th component of complement in his serum (C7 homozygous deficiency). Both parents are C7 heterozygous-deficient. Complement components in functional and immunochemical tests, HLA-A,B antigens, HLA-D (MLC) determinants, the Bf system, glyoxalase I and B cell antigens were determined. No evidence for linkage between the immunogenetic linkage group on chromosome 6 and gene(s) controlling the synthesis of the 7th component of complement was obtained. Only the genes controlling components of the initiating rather than the membrane attack unit of complement are linked to the HLA region.

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