+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of lung damage in mice following administration of tert butylhydroquinone

, : Lack of lung damage in mice following administration of tert butylhydroquinone. Drug & Chemical Toxicology an International Journal for Rapid Communication 7(4): 335-344

tert-Butylhydroquinone (TBHQ), a phenolic antioxidant used in foods, was tested for its potential to produce lung damage in mice similar to that seen following administration of butylated hydroxytoluene (BHT). Male mice (CRL:CD-1) were given single i.p. injections of 62.5, 125, 250 or 500 mg/kg TBHQ or 300, 625 or 1230 mg/kg BHT in corn oil. Survivors were killed 5 days after treatment and the lungs were removed, weighed and processed for histologic examination. Lung weights of the TBHQ treated animals were comparable to the controls, while BHT produced a statistically significant increase in lung weight. Histologically, BHT produced hyperplasia of pulmonary pneumocytes as previously reported. No treatment-related lung lesions were seen in the TBHQ mice. TBHQ did not produce pulmonary lesions in mice.


Other references

DaviesMorel,M.C.G., 2008: Selection of the mare and stallion for breeding. This chapter presents the criteria and techniques in the selection of stallions and mares for reproductive performance, depending on personal choice and the value of the breeding stock and potential offspring.

Ortigues-Marty, I.; Thomas, E.; Prévéraud, D.P.; Girard, C.L.; Bauchart, D.; Durand, D.; Peyron, A., 2006: Influence of maturation and cooking treatments on the nutritional value of bovine meats: Water losses and vitamin B12. The aim of the study was to determine the influence of maturation and of cooking processes on water losses and on the vitamin B12 content of meat. Three types of muscle (Longissimus lumborum, Longissimus thoracis and Triceps brachii) were sampled...

Ahlstedt, S.; Hanson, L.A., 1975: Complement activation in relation to protective function of antibodies to Escherichia coli O antigens. The relation between complement activation in an indirect hemolysis assay of E. coli O antibodies and their protective function in experimentally infected mice was analyzed. The antibody amounts and avidities were estimated in antisera and in IgG...

Adams, S., 1994: New soybeans open the planting window. Agricultural research 42(6): 18-19

Minto, A.W.; Wilson, H.M.; Brown, P.A.J.; Rees, A.J.; Haites, N.E.; Macleod, A.M., 1997: Rapid induction of glomerular TGF beta2 and beta3, but not TGF beta1, in acute mesangio-proliferative glomerulonephritis. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 503A, Sept

Dimitriou, A.; Tsoukali, H., 1998: Methyl bromide and bromide ion in soil after experimental greenhouse fumigation. Bulletin of Environmental Contamination & Toxicology 61(6): 695-701, Dec

Otani, K.; Suzuki, A.; Matsumoto, Y.; Shibuya, N.; Sadahiro, R.; Enokido, M., 2014: Correlations of interpersonal sensitivity with negative working models of the self and other: evidence for link with attachment insecurity. It has been suggested that interpersonal sensitivity, a personality trait associated with depression and anxiety disorders, is linked with attachment insecurity. To confirm this link, we studied the correlations of interpersonal sensitivity with w...

Peterson, O.H.; Iwatsuki, N., 1978: The role of calcium in pancreatic acinar cell stimulus-secretion coupling: an electrophysiological approach. Annals of the New York Academy of Sciences 307: 599-617

Kobayashi T.; Kobayashi K.; Tokiya R.; Asakura Y.; Kato K.; Ohmura K.; Sato M., 1986: Subcapsular vessels of normal liver. Scanning-electron microscopy using a chemical-digestion method after mechanical stripping of liver capsule helps to observe three-dimensional subcapsular microstructures. Lobular parenchyma was covered with a thin membrane of connective tissue. A...

Ramakrishnan P.S., 1981: Ecological impact of slash and burn agriculture on forested ecosystem of northeastern india. Proceedings of the International Botanical Congress 13: 105