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Lack of lung damage in mice following administration of tert butylhydroquinone


, : Lack of lung damage in mice following administration of tert butylhydroquinone. Drug & Chemical Toxicology an International Journal for Rapid Communication 7(4): 335-344

tert-Butylhydroquinone (TBHQ), a phenolic antioxidant used in foods, was tested for its potential to produce lung damage in mice similar to that seen following administration of butylated hydroxytoluene (BHT). Male mice (CRL:CD-1) were given single i.p. injections of 62.5, 125, 250 or 500 mg/kg TBHQ or 300, 625 or 1230 mg/kg BHT in corn oil. Survivors were killed 5 days after treatment and the lungs were removed, weighed and processed for histologic examination. Lung weights of the TBHQ treated animals were comparable to the controls, while BHT produced a statistically significant increase in lung weight. Histologically, BHT produced hyperplasia of pulmonary pneumocytes as previously reported. No treatment-related lung lesions were seen in the TBHQ mice. TBHQ did not produce pulmonary lesions in mice.

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