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Lack of opiate receptor involvement in centrally induced calcitonin analgesia

, : Lack of opiate receptor involvement in centrally induced calcitonin analgesia. Life Sciences 22(11): 971-978

Calcitonin (CT) injected into the brain ventricles of conscious rabbits induced an analgesia not reversible by naloxone which could be repeatedly elicited (for 5 days), while tolerance to morphine developed. CT and morphine synergized in vivo when administered ICV [intracerebroventricularly] in combination. CT did not alter electrically-induced contractions of guinea pig myenteric plexus-longitudinal muscle and no displacement of 3H-dihydromorphine by CT was observed in brain opiate receptor preparations. The mechanism of centrally induced CT analgesia may be opiate-independent.


PMID: 205748

DOI: 10.1016/0024-3205(78)90362-4

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