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Lack of potentiation of vincristine induced neuro toxicity by vp 16 213 4' demethyl epi podophyllo toxin beta d ethylidene glucoside


, : Lack of potentiation of vincristine induced neuro toxicity by vp 16 213 4' demethyl epi podophyllo toxin beta d ethylidene glucoside. American Journal of Clinical Oncology 6(3): 327-330

The neurologic toxicity data from a randomized trial of vincristine and VP-16-213 in small cell carcinoma of the lung were analyzed. Of 102 patients evaluable for toxicity, 50 were treated with a combination of cyclophosphamide, adriamycin, and vincristine (CAV) and 52 received this regimen plus VP-16-213. Vincristine dosage was the same in both arms of the study. When analyzed by severity, neurologic complications were similar in both treatment groups: Grade 1-2 neurotoxicity occurred in 55% of patients on both arms and grade 3-4 neurotoxicity was observed in 6 (12%) patients on the CAV arm and 4 (8%) on the CAV-VP-16-213 arm. Addition of VP-16-213 to vincristine did not potentiate vincristine-induced neurotoxicity when administered in this dose-schedule relationship.

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