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Lack of proliferation to allo antigen in a sibling of 2 infants with severe combined immuno deficiency

, : Lack of proliferation to allo antigen in a sibling of 2 infants with severe combined immuno deficiency. Clinical Immunology & Immunopathology 24(2): 286-291

A 6-yr-old female sister of 2 infants who died from complications caused by severe combined immunodeficiency, is reported. Although clinically asymptomatic, she showed the following laboratory immunological abnormalities: negative mixed lymphocyte culture response, decreased number of E-rosettes, decreased response to pokeweed mitogen and concanavalin A in spite of normal response to phytohemagglutinin, a high number of IgD-positive B cells, and normal Ig level. The importance of these findings is stressed and similar models are discussed as examples of complexity of the immune functions in animals and men.


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