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Lack of promoting effect of sodium chlorate and potassium chlorate in two stage rat renal carcinogenesis

, : Lack of promoting effect of sodium chlorate and potassium chlorate in two stage rat renal carcinogenesis. Journal of the American College of Toxicology 4(6): 331-338

Sodium chlorate (NaClO3) and potassium chlorate (KClO3), which are byproducts of water disinfection with chlorine dioxide (ClO2), were tested for potential promoting effect in two-stage rat renal carcinogenesis. Three groups of 15 male F344 rats were given N-ethyl-N-hydroxyethylnitrosamine (EHEN) at the level of 0.5% for the first 2 weeks during the initiation phase. Thereafter, the rats were treated orally for 25 weeks with NaClO3 (1%), KClO3 (1%), or distilled water (DW). Three other groups (controls) were treated similarly, except that DW was given in the initiation phase. All animals survived for the duration of the experiment. Renal neoplastic lesions were classified histologically as dysplastic foci (DF) and renal cell tumors (RCT). The number of these lesions per unit area, in six sections from each kidney, was determined microscopically. There were no statistically significant differences in the incidences and in the mean number of DF and RCT of the kidney between compound- and DW-treated rats initiated with EHEN. It is concluded that NaClO3 and KClO3 show no promoting effet in renal rat carcinogenesis under the conditions of this study.


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Bischoff, Wolfgang, 2005: Die Echten Eidechsen der Familie Lacertidae - eine Uebersicht. Draco 6(1): 4-27 Nr 21

Ananiadou, O.; Karaiskos, T.; Givissis, P.; Drossos, G., 2010: Operative stabilization of skeletal chest injuries secondary to cardiopulmonary resuscitation in a cardiac surgical patient. Chest injury, including sternal and rib fractures, is the most common complication of cardiopulmonary resuscitation (CPR) that usually heals spontaneously. However, a small subset of patients has fractures that need mechanical treatment. We presen...

Straeter, J.; Ruff, M.; Henne, C.; Moeller, P., 1994: PMA-activation of peripheral blood and tonsillar B lymphocytes induces large adhesive cells reminiscent of large extrafollicular B cells. Pathology Research & Practice 190(3): 297

Martin, N.F.; Robinson, H.N., 1997: Topical composition for treatment of blepharitis. Official Gazette of the United States Patent & Trademark Office Patents 1196(4): 2691, March 25

Montero Domínguez, J.; Gil Fernández, J.; Venero Montero, F., 1976: Pulmonary embolism and maximum elevation of enzymes. Revista Clinica Espanola 142(1): 81-85

Schenk D.; Derdak S.; Komadina K.; Pickard J.; Strollo P.; Lewis R.; Patefield A.; Chambers S.; Henderson J.; Tomski S., 1991: Comparison of the wang 18 19 gauge histology needle and 22 gauge cytology needle in the staging of bronchogenic carcinoma. American Review of Respiratory Disease 143(4 PART 2): A65

Ishizu, A., 1993: Bleaching of kraft pulp with hemicellulase. A review of the use of enzymes in bleaching of Kraft pulp.

Gómez-Estrada, H.; Morales-Ortiz, R.; González-Mendoza, A.; Barba-Rubio, J.; Ceja-Mendoza, S., 1983: Peroxidase deficiency in histiocytes of patients with nodular lepromatous leprosy. Archivos de Investigacion Medica 14(2): 127-137

Levy, J.R.; Hug, V., 1993: Nuclear protein-binding analysis of a GC-rich insulin-receptor promoter regulatory region. We previously demonstrated that activation of the insulin-receptor promoter occurs between Xho I and HindIII restriction enzyme sites located 877 and 578 bp upstream, respectively, from the translational initiation site. Deletion mutants 5' o...

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