geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis


, : Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis. New England Journal of Medicine 318(11): 671-676

To determine how much insulin-dependent diabetes increases a woman's risk of giving birth to a malformed infant and how that risk is influenced by metabolic control, we followed 347 diabetic and 389 control women who enrolled in the study within 21 days of conception (the early-entry group) and 279 diabetic women who entered later (the late-entry group). We detected major malformations in the infants of 4.9 percent of the early-entry diabetic women, 2.1 percent of the controls, and 9.0 percent of the late-entry diabetic women. Malformation rates were significantly higher among offspring of early-entry diabetic women than among those of controls (odds ratio, 2.45; lower one-sided 95 percent confidence limit, 1.12; P = 0.027), and higher among late-entry than among early-entry diabetic women (odds ratio, 1.91; lower one-sided 95 percent confidence limit, 1.07; P = 0.032). Mean blood glucose and glycosylated hemoglobin levels during organogenesis were not significantly higher in women whose infants were malformed. Hypoglycemia (glucose, less than or equal to 50 mg per deciliter [2.8 mmol per liter]) was not significantly more common in the same group. Hyperglycemia and glycosylated hemoglobin were not correlated with malformation. The data suggest that more sensitive measures are needed to identify the teratogenic mechanisms, or that not all malformation can be prevented by good glycemic control. Despite the increased malformation rate among infants of the early-entry diabetic women, as compared with the controls, the more favorable outcome seen in the former group as compared with the late-entry group justifies the attempt to achieve good metabolic control around the time of conception.

US$19.90

PMID: 3344018

DOI: 10.1056/NEJM198803173181104


Other references

Saayman G.S., 1973: Effects of ovarian hormones on the sexual skin and behavior of ovariectomized baboons papio ursinus under free ranging conditions. Phoenix, Charles H (Ed ) Symposia Of The Fourth International Congress Of Primatology, Vol 2 Primate Reproductive Behavior Portland, Oreg , U S A , August 15-18, 1972 Ix+125p Illus S Karger Ag: Basel, Switzerland; New York, N Y , U S A 64-98

Parasjuk, I.P., 1969: The effect of intensive rearing of pigs on their growth and productivity. In 5 experiments, 252 Large Whites were reared on standard rations (groups 1 and 4), or on 25 and 11 % more F.U. than the standard (groups 2 and 3 resp.). Litter size in groups 1 and 4, following mating at 10.7 and 10.5 mth, averaged 9.8 and 9.9 r...

Mal tsev K.A.; Klyuyev Y.A., 1993: Degree of nitrogen aggregation in diamonds and features of diamond formation. Geokhimiya 1993(9): 1354-1357

Farias Rodriguez, R.; Mellor, R.B.; Arias, C.; Pena Cabriales, J.J., 1998: The accumulation of trehalose in nodules of several cultivars of common bean (Phaseolus vulgaris) and its correlation with resistance to drought stress. In greenhouse pot trials, 9 P. vulgaris cultivars were grown in the presence of natural microflora without exogenous rhizobial inoculation. Nodules were harvested 30 days after sowing (early flowering stage) and the presence of trehalose determine...

Markley, John L., 1997: Shared instrumentation resources for solution state nuclear magnetic resonance investigations of biomolecules. FASEB Journal 11(9): A1122

Khanna, P.K.; Mittar, D.; Garcha, H.S., 1994: Pleurotus spore allergy An overview. Nair, M C Advances in mushroom biotechnology 120-126

Tanwani, L.K.; Lohano, V.; Broadstone, V.L.; Mokshagundam, S.Prakash.L., 2002: Minimal change nephropathy and graves' disease: report of a case and review of the literature. To describe a possible association between Graves' disease and nephrotic syndrome attributable to minimal change nephropathy and to review the literature related to renal diseases in patients with Graves' disease. The clinical, laborator...

Krietsch, W.K.G.; Krietsch, H.; Kaiser, W.; Dunnwald, M.; Kuntz, G.W.K.; Duhm, J.; Bucher, T., 1977: Hereditary deficiency of phospho glycerate kinase ec 2.7.2.3 a new variant in erythrocytes and leukocytes not associated with hemolytic anemia. An X-chromosome linked phosphoglycerate kinase [EC 2.7.2.3] deficiency in erythrocytes and leukocytes was discovered in a large German kindred. Seven males of 2 generations have only 21% of the normal enzyme activity in their erythrocytes, and 12...

Green, A.M.; Budagyan, K.; Hayer, K.E.; Reed, M.A.; Savani, M.R.; Wertheim, G.B.; Weitzman, M.D., 2017: Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint. Mutational signatures in cancer genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a therapeutic vulnerability. Elevated APOBEC3B expression has been detected in solid tumors, but expression of APOBEC3A (A3A)...

Sirotti A., 1967: Nummulitidae and Orbitoididae from the 'Molasse di Rio Giordano' (middle-upper Eocene, northern modenese Apennines). Systematic descriptions, 16 species, Italy.