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Lack of relationship between toxicity and bone marrow cell colony stimulating activity of endo toxin preparations


, : Lack of relationship between toxicity and bone marrow cell colony stimulating activity of endo toxin preparations. Proceedings of the Society for Experimental Biology & Medicine 163(1): 15-18

The release of colony stimulating factor (CSF) by [Serratia marcescens] endotoxin [etox] was studied using several etox preparations differing greatly in their toxicities measured as mouse LD50. No correlation was found between lethality and CSF release. The toxic effect of etox is not required for the generation of CSF. The component in the polysaccharide-rich and lipid-free, non-endotoxic, partially hydrolyzed etox breakdown product (called PS) which can stimulate the CSF release in mice is sensitive to periodate oxidation.

US$29.90

PMID: 6965428


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Soumya, R.; Carl, H.; Vani, R., 2016: l-carnitine as a Potential Additive in Blood Storage Solutions: A Study on Erythrocytes. Erythrocytes undergo various changes during storage (storage lesion) that in turn reduces their functioning and survival. Oxidative stress plays a major role in the storage lesion and antioxidants can be used to combat this stress. This study eluc...

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