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Lack of relationship between toxicity and bone marrow cell colony stimulating activity of endo toxin preparations

, : Lack of relationship between toxicity and bone marrow cell colony stimulating activity of endo toxin preparations. Proceedings of the Society for Experimental Biology & Medicine 163(1): 15-18

The release of colony stimulating factor (CSF) by [Serratia marcescens] endotoxin [etox] was studied using several etox preparations differing greatly in their toxicities measured as mouse LD50. No correlation was found between lethality and CSF release. The toxic effect of etox is not required for the generation of CSF. The component in the polysaccharide-rich and lipid-free, non-endotoxic, partially hydrolyzed etox breakdown product (called PS) which can stimulate the CSF release in mice is sensitive to periodate oxidation.


PMID: 6965428

Other references

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Piludu, M.; Medda, L.; Cugia, F.; Monduzzi, M.; Salis, A., 2016: Silver Enhancement for Transmission Electron Microscopy Imaging of Antibody Fragment-Gold Nanoparticles Conjugates Immobilized on Ordered Mesoporous Silica. Ordered mesoporous silica (OMS) materials are receiving great attention as possible carriers for valuable but unstable drugs as, for example, therapeutic proteins. A key issue is to prove that the therapeutic protein is effectively able to penetra...

Soumya, R.; Carl, H.; Vani, R., 2016: l-carnitine as a Potential Additive in Blood Storage Solutions: A Study on Erythrocytes. Erythrocytes undergo various changes during storage (storage lesion) that in turn reduces their functioning and survival. Oxidative stress plays a major role in the storage lesion and antioxidants can be used to combat this stress. This study eluc...

Bolotina I.A.; Dudkin S.M.; Lugauskas V.Yu; Khandanyan A.Zh; Leshchinskaya I.B., 1979: Rnase of bacillus intermedius 7p determination of the secondary structure in solution by the circular dichroism method. Soviet Journal of Bioorganic Chemistry 5(2): 143-148

Pino, J.A.; Rosado, A.; Fuentes, V., 1999: Composition of the essential oil of Melissa officinalis L. from Cuba. The essential oil of dried herb of Melissa officinalis L. grown in Cuba was subjected to GC/MS investigation. Among the 28 constituents separated, 17 were identified (88% of the oil composition). The oil consisted mainly of neral (29.9%) and geran...

Gusta, L.V., 1986: The induction and maintenance of cold hardiness in herbaceous plants. This paper was presented at the 84th Nordiske Jordbrugsforskeres Forening Seminar, entitled "Overwintering of agricultural crops", held in Jokioinen, Finland, in June 1986. The physiology and biochemistry of winter hardiness in winter ce...

Whitfield, A.G., 1969: Women medical graduates of the University of Birmingham 1959-63. British Medical Journal 3(5661): 44-46

Saidaliev, A., 1967: Growth features of the ligamentum arteriosum. The ligamen-tum arteriosum was measured in 220 cadavers of both sexes from newborn infants to adults of 88 yrs. Up to 7 yrs. of age, projection of the ligamentum was at the level of the articulation of the 2nd rib with the sternum, or in the 2nd i...

Demarcq, G.; Schoepfer, P., 1990: Les pectinides du Miocene de Suisse occidentale. Near 200 Pectinids gathered from the "helvetian" facies (Upper Marine Molasse, Early Miocene) of Western Switzerland have been revised and determined. They are grouped into 13 species, 6 of which are mentioned for the first time in the s...