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Lack of relevance of kinetic parameters for exocellular dd peptidases to cephalosporin minimum inhibitory concentrations

, : Lack of relevance of kinetic parameters for exocellular dd peptidases to cephalosporin minimum inhibitory concentrations. Antimicrobial Agents & Chemotherapy 29(5): 774-780

MICs of a set of cephalosporins against a variety of gram-positive and gram-negative pathogens showed no strong correlations with the rate at which these inhibitors acylate or are deacylated by .beta.-lactam-sensitive Dd-peptidases excreted by Streptomyces sp. strain R61 and Actinomadura sp. strain R39.


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