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Lack of responsiveness of c 3h hej macrophages to lipo poly saccharide the cellular basis of lipo poly saccharide stimulated metabolism


, : Lack of responsiveness of c 3h hej macrophages to lipo poly saccharide the cellular basis of lipo poly saccharide stimulated metabolism. Journal of Immunology 122(3): 932-935

The rate of glucose utilization was used as a measure of LPS[lipopolysaccharide]-induced activation of cultures of C3H/HeN and C3H/HeJ [mouse] spleen cells, peritoneal cells and purified peritoneal adherent cells. Peritoneal cells utilized 40-60 times more glucose than did spleen cells and purified adherent monolayers were more active than mixed peritoneal cells, suggesting that only macrophage metabolism was being measured. The cell preparations for C3H/HeJ mice were not activated by Escherichia coli K235 LPS prepared by extensive phenol extraction, whereas C3H/HeN cells were activated by that LPS. Cells from both strains were activated by a commercially obtained E. coli 0111:B4 LPS and butanol-extracted K235 LPS. The addition of 10% C3H/HeN spleen cells to C3H/HeJ peritoneal cells resulted in a marked enhancement of glucose utilization. LPS-induced enhancement of macrophage metabolism may occur by direct action of LPS on macrophages and indirectly through activated lymphocytes.

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