+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of selective killing by steroids in normal and malignant cells

, : Lack of selective killing by steroids in normal and malignant cells. Journal of Cellular Physiology 103(3): 429-433

Using a colony formation assay, the cytotoxic effects of steroids and an anti-steroid on an established human breast tumor line and two human diploid fibroblast strains were studied. Experiments involving 17 a-estradiol, 17 beta-estradiol, dexamethasone, cortisone, dihydrotestosterone, and the anti-estrogen Tamoxifen showed no killing at concentrations below 10(-7)M following a 24-hour exposure to these agents. A maximum of 80% killing was observed at 10(-5)M with dexamethasone in one fibroblast strain and at the same dose of 17 beta-estradiol in the breast tumor line. The extent of killing observed is insufficient to account for many of the clinical remissions observed with steroid therapy. The data also suggest that at therapeutic doses, there is no selective killing of malignant cells by these agents.


PMID: 7400225

DOI: 10.1002/jcp.1041030308

Other references

Pande, B.R.; Martischnig, K.M.; Feinmann, L., 1970: A two-year follow-up of 181 sputum-positive tuberculosis patients treated in Gateshead between 1961 and 1966. Tubercle 51(1): 39-43

Minster, S.Tepaeru.; Elliffe, D.; Muthukumaraswamy, S.D., 2011: Emergent stimulus relations depend on stimulus correlation and not on reinforcement contingencies. We aimed to investigate whether novel stimulus relations would emerge from stimulus correlations when those relations explicitly conflicted with reinforced relations. In a symbolic matching-to-sample task using kanji characters as stimuli, we arra...

Lark, A.L.; Livasy, C.A.; Millikan, R.C.; Dressler, L.G.; Cowan, D.W.; Tse, J.; Little, D.G.; Cance, W.G., 2003: Focal adhesion kinase expression in invasive breast carcinoma. Modern Pathology 16(1): 38A, January

Withers-Ward, E.S.; Jowett, J.B.; Stewart, S.A.; Xie, Y.M.; Garfinkel, A.; Shibagaki, Y.; Chow, S.A.; Shah, N.; Hanaoka, F.; Sawitz, D.G.; Armstrong, R.W.; Souza, L.M.; Chen, I.S., 1997: Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair. The human immunodeficiency virus type 1 (HIV-1) vpr gene is an evolutionarily conserved gene among the primate lentiviruses HIV-1, HIV-2, and simian immunodeficiency viruses. One of the unique functions attributed to the vpr gene product is the ar...

Heilmeyer, L., 1958: Cortisone treatment of bacterial infections. Seminar International 7(2): 2-5

Lehninger A.; Brand M.; Reynafarje B., 1977: Correlation of the proton per site ratio of mitochondrial electron transport and the proton atp ratio of atp hydrolysis. Federation Proceedings 36(3): 726

Teh, B.Aun.; Choi, S.Bing.; Musa, N.; Ling, F.Ling.; Cun, S.Too.Wei.; Salleh, A.Bakar.; Najimudin, N.; Wahab, H.A.; Normi, Y.M., 2014: Structure to function prediction of hypothetical protein KPN_00953 (Ycbk) from Klebsiella pneumoniae MGH 78578 highlights possible role in cell wall metabolism. Klebsiella pneumoniae plays a major role in causing nosocomial infection in immunocompromised patients. Medical inflictions by the pathogen can range from respiratory and urinary tract infections, septicemia and primarily, pneumonia. As more K. pn...

Turtle, E.E., 1977: Agricultural pesticides and the environment in the developing world. An introductory outline. Attention is drawn to the increasing use of chemicals, especially chlorinated hydrocarbons such as DDT and BHC, for the control of agricultural pests in developing countries. Proposals by FAO for stimulating and coordinating the monitoring of the...

Mathers, T.G., 1925: The Medical Witness : Historical Sketch of the Medical Witness. Canadian Medical Association Journal 15(5): 461-467

Deng, H-ou.; Li, D-feng.; Zhang, W-jie.; Zhi, X-mei.; Xu, L.; Wu, W., 2013: Factors associated with acute febrile reaction in elderly patients receiving intravenous zoledronic acid for osteoporosis. To survey the incidence of acute febrile reaction in elderly patients receiving intravenous zoledronic acid for osteoporosis and identify the related factors. Thirty-eight elderly patients with osteoporosis were hospitalized and treated with intra...