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Lack of short term effects of cigarette smoking on bronchial sensitivity to histamine and methacholine

, : Lack of short term effects of cigarette smoking on bronchial sensitivity to histamine and methacholine. European Journal of Respiratory Diseases 63(6): 535-542

The short-term effects of cigarette smoking on the bronchial responsiveness of 20 current [human] smokers to inhaled histamine and methacholine were examined. The inhalation tests were performed by the 2-min quiet breathing technique and the concentrations of histamine or methacholine to cause a 20% fall in the forced expired volume in 1 s (FEV1) were calculated. Smoking prior to an inhalation test produced no significant change from control inhalation tests. Repeated inhalation tests at 40 min intervals, with both histamine and methacholine, did not demonstrate a change in sensitivity.


PMID: 6756949

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