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Lack of simple relationship between endogenous growth hormone and acid ethanol soluble nonsuppressible insulin like activity related peptides


, : Lack of simple relationship between endogenous growth hormone and acid ethanol soluble nonsuppressible insulin like activity related peptides. Journal of Clinical Endocrinology and Metabolism 45(2): 330-338

Using a liver membrane radioreceptor assay that is specific for NSILA [acid ethanol soluble nonsuppressible insulin-like activity] and related compounds, it was shown that plasma NSILA, like plasma somatomedin, is low in hypopituitary patients and rises acutely after i.v. hGH [human growth hormone]. In contrast to the somatomedins, however, NSILA, as measured in this assay, is not elevated in the sera of acromegalic patients. In an attempt to understand better the interrelationship between NSILA and endogenous GH, a variety of physiologic and pharmacologic stimuli were studied. NSILA rose after oral glucose at a time when hGH levels were falling. Conversely, after i.v. insulin or estrogen, NSILA levels fell at a time when hGH levels were rising. Oral L-dopa and i.v. glucagon both produced substantial rises in plasma GH without causing an acute change in NSILA related peptides. The most striking dissociation between endogenous hGH and NSILA related peptides was observed during a 48-72 h fast. In normal subjects fasting produced a rise in GH and a dramatic fall in NSILA whereas in obese subjects, NSILA rose during fasting despite no change in plasma GH. Within the context of these studies, there was no apparent correlation between changes in endogenous GH concentration and plasma NSILA or NSILA related compounds as measured by this radioreceptor assay.

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