+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of specific tritium labeled prazosin binding sites in dog and rabbit cerebral arteries

, : Lack of specific tritium labeled prazosin binding sites in dog and rabbit cerebral arteries. Life Sciences 35(21): 2169-2176

To explore the characteristics of .alpha. adrenergic receptors on cerebrovascular smooth muscle, specific binding sites for the .alpha.1 adrenergic ligand, (3H) prazosin, were studied in blood vessel homogenates. No specific (3H) prazosin binding was found in either rabbit or dog cerebral arteries, but specific binding was demonstrated in the rabbit saphenous and ear arteries. In the ear artery 3H-prazosin binding was saturable with a Kd of 0.51 .+-. 0.20 nM and a Bmax of 89 .+-. 29 fmol/mg protein. To confirm the adequacy of the membrane preparation, homogenates of both dogs and rabbit cerebral arteries showed saturable specific binding with 2 different ligands: 1 for muscarinic receptors, [3H](-) quinclidinyl benzilate (QNB) and 1 for .alpha.2 adrenergic receptors, (3H) yohimbine. The results of these studies demonstrate a lack of .alpha.1 adrenergic receptors on cerebral blood vessels, confirming functional studies showing only a weak contractile response to norepinephrine.


Other references

Vrabec, M., 1986: Compensatory head positions in muscle palsies. American Journal of Ophthalmology 101(3): 383-384

Volkova N.I.; Mel nichenko A.K.; Gofen G.I.; Varziyeva T.B.; Pachadzhanov D.N., 1994: Geochemical characteristics of metapelites from Fan-Karategin greenstone belt. Geokhimiya 1994(5): 671-680

Anonymous, 1972: Using generic names: Pakistan leads the world. Drug and Therapeutics Bulletin 10(15): 60-60

MARTI.M.RTINEK.C.RISTIN.L.MES.E.ISABET.S.GMUND.M.CHAE.D.RNDORFER.J.SE.A.CHINGER.S.EGMUN.W.NTER.H.NS-JOACHI.N.SSER.H.LMU.P.śRERFELLNER, 2012: Clinical Impact of a New Open-Irrigated Radiofrequency Catheter with Direct Force Measurement on Atrial Fibrillation Ablation. Electrode-tissue contact is crucial for adequate lesion formation in radiofrequency catheter ablation (RFCA). We assessed the impact of direct catheter force measurement on acute procedural parameters during RFCA of atrial fibrillation (AF). Fifty...

Schwarz, G.A.; Yang, D.C.; Noone, E.L., 1964: Meningoencephalomyelitis With Epidemic Parotitis. Clinicopathologic Report. Archives of Neurology 11: 453-462

Usery, R.D.; Enoki, T.A.; Wickramasinghe, S.P.; Weiner, M.D.; Tsai, W-Chyan.; Kim, M.B.; Wang, S.; Torng, T.L.; Ackerman, D.G.; Heberle, F.A.; Katsaras, J.; Feigenson, G.W., 2017: Line Tension Controls Liquid-Disordered + Liquid-Ordered Domain Size Transition in Lipid Bilayers. To better understand animal cell plasma membranes, we studied simplified models, namely four-component lipid bilayer mixtures. Here we describe the domain size transition in the region of coexisting liquid-disordered (Ld) + liquid-ordered (Lo) ph...

Zoumi, A.; Lu, X.; Kassab, G.S.; Tromberg, B.J., 2004: Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy. The microstructural basis for the mechanical properties of blood vessels has not been directly determined because of the lack of a nondestructive method that yields a three-dimensional view of these vascular wall constituents. Here, we demonstrate...

Rasche, H., 1992: Long-term therapy after an acute myocardial infarct. Deutsche Medizinische Wochenschrift 117(44): 1696-1697

Graham-Brown, R., 1996: Managing adults with atopic dermatitis. The majority of the patients with atopic dermatitis (AD) that dermatologists see present to us in childhood. For most patients there is a relatively limited period during which AD is a major influence on their lives. For some patients, however, AD...

Simbulan Rosenthal, C.M.G.; Rosenthal, D.S.; Ding, R.; Jackman, J.; Smulson, M.E., 1996: Depletion of nuclear poly polymerase by antisense RNA expression Influence on genomic stability, chromatin organization, DNA repair, and DNA replication. Cohn, W E , Moldave, K Progress in Nucleic Acid Research and Molecular Biology 135-156