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Lack of specificity of brain gangliosides in the modulation of lymphocyte activation

, : Lack of specificity of brain gangliosides in the modulation of lymphocyte activation. Yale Journal of Biology and Medicine 58(5): 459-467

A potential role for glycolipid gangliosides to act as immunomodulating agents has been suggested. Most studies have employed brain gangliosides. We have systematically investigated highly purified murine brain gangliosides for their ability to modulate lymphocyte activation. All sialic acid classes of ganglioside inhibited lipopolysaccharide (LPS)-induced antibody secretion and all polysialated gangliosides inhibited LPS-induced DNA synthesis. Monosialated gangliosides had no effect on DNA synthesis induced by LPS, 8-BrcGMP-induced DNA synthesis was also inhibited, suggesting that a negative signal was delivered to B lymphocytes by co-cultivation with exogenous gangliosides. The lack of specificity with respect to sialic acid class observed in these studies suggests that further investigation of an immunomodulatory role for gangliosides focus on endogenous lymphocyte gangliosides.


PMID: 4090532

Other references

Anderson, R.J., 1885: Note on the Peritoneum of the Seal. Journal of Anatomy and Physiology, XIX 228 & 229

Arkhangel'skiĭ, G.V.; Pribytkov, G.I., 1990: Moscow neuropathologist Georgiĭ Ivanovich Pribytkov. Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 90(12): 77-79

Norton G.R.; Dinardo P.A.; Barlow D.H., 1983: Predicting phobics response to therapy a consideration of subjective physiological and behavioral measures. Canadian Psychology 24(1): 50-58

Neophytou, A.M.; Picciotto, S.; Hart, J.E.; Garshick, E.; Eisen, E.A.; Laden, F., 2014: A structural approach to address the healthy-worker survivor effect in occupational cohorts: an application in the trucking industry cohort. Occupational cohort studies are often challenged by the Healthy Worker Survivor Effect, which may bias standard methods of analysis. G-estimation of structural failure time models is an approach for reducing this type of bias. Accelerated failure...

Wright, J.E.; Hayes, M.J.; Subramanyam, V.; Soloway, A.H., 1977: Chemo immuno therapy of cancer part 3 analytical measurement of chemical half lives of mono functional alkylators. The objective of this study is the measurement of the rates of hydrolysis of a series of chloroethyl sulfide derivatives, under simulated physiological conditions. Interferences encountered with the conventional spectrophotometric method prompted...

Michel Rabinowicz; Marie Calvet; Michael J.T.plis, 2012: Possible layering of mantle convection at the top of the Iceland Hotspot a crosscheck between 3-D numerical models and gravimetric, seismic and petrological data. D numerical models describing convection cells that may develop in a buoyant layer over an upper-mantle hotspot are developed. are compared with those of an alternative model, which assumes an upper partially molten layer having the same density a...

Dzielak D.J.; Norman R.A.Jr, 1985: Renal nerves are not necessary for onset or maintenance of deoxycorticosterone salt hypertension in rats. The effect of renal denervation on the onset and maintenance of mineralocorticoid-salt [deoxycorticosterone (DOC)-salt] hypertension was determined. A unilateral right nephrectomy was performed on all rats. Rats were divided into renal-denervated...

Ciarlet, M.; Conner, M.E.; Finegold, M.J.; Estes, M.K., 2001: Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infection. Group A rotaviruses are major pathogens causing acute gastroenteritis in children and animals. To determine if group A rotavirus replicates and induces disease in rats, antibody-negative Lewis neonatal or adult rats were inoculated orally with tis...

Jain, A.; Bacolla, A.; Chakraborty, P.; Grosse, F.; Vasquez, K.M., 2010: Human DHX9 helicase unwinds triple-helical DNA structures. Naturally occurring poly(purine.pyrimidine) rich regions in the human genome are prone to adopting non-canonical DNA structures such as intramolecular triplexes (i.e., H-DNA). Such structure-forming sequences are abundant and can regulate the expr...

Gaffuri, S., 1960: Reticulocytemia and ovarian hormones. Clinico-experimental study. Minerva Ginecologica 12: 827-830