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Lack of stimulation of phasic luteinizing hormone release by catechol estrogens in the rat


, : Lack of stimulation of phasic luteinizing hormone release by catechol estrogens in the rat. Life Sciences 26(9): 743-748

The 2-hydroxylated metabolites of estrone (E1) and estradiol (E2) were tested for their ability to induce an increase in the concentration of LH [luteinizing hormone] in the serum of the prepuberal male or female rat. Neither catechol estrogen was capable of inducing increases in the concentration of LH in the serum of rats of either sex, but E1 and E2 induced a surge in serum LH in the prepuberal female rats. The role that catechol estrogens might play in the control of phasic LH release is negligible.

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