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Lack of substantial neuroendocrine changes in short term high dose cadmium treated rats

, : Lack of substantial neuroendocrine changes in short term high dose cadmium treated rats. Rivista di Tossicologia Sperimentale e Clinica 15(3): 135-140

A 35-day Cd 5 mg/kg/die treatment by oral gavage did not modify adrenal cortex, Leydig cells, thyroid function or autacoid 5-hydroxytryptamine peripheral metabolism but increased urinary catecholamine excretion and decreased hypothalamic 5-hydroxytryptamine levels. Remarkable Cd concentration was found at the renal and adrenal level, thymus and spleen on a decreasing scale. Cd brain and testicular concentrations did not change, neither were their histological features appreciably modified. Renal tissue showed marked degenerative changes. The increase in catecholamine excretion may indicate an activation of chromaffin tissue and peripheral adrenergic neurotransmission. Hypothalamic 5-hydroxytryptamine changes focus attention on possible subtle changes of neurotransmitters at the median eminence area, involved in the pituitary control, with a blood-brain barrier more permeable than other areas of the brain.


Other references

Jadin P.; Vaast P., 1990: Estimation of fertilizer requirements in soils to be used for cocoa plantation in the litime togo. Cafe Cacao The 34(3): 179-188

Lis K.K.¶nnecke; Millard F.C.ffin; Philippe Charvis, 1998: Early development of the southern Kerguelen Plateau (Indian Ocean) from shallow wide-angle ocean bottom seismometer and multichannel seismic reflection data. Journal of Geophysical Research: Solid Earth 103(B10): 24085-24108

Zhao, Y.; Xu, D.; Jiang, Y.; Zhang, L., 2011: Dual functions of interferon regulatory factors 7C in Epstein-Barr virus-mediated transformation of human B lymphocytes. Epstein-Barr virus (EBV) infection is associated with several human malignancies. Interferon (IFN) regulatory factor 7 (IRF-7) has several splicing variants, and at least the major splicing variant (IRF-7A) has oncogenic potential and is associate...

Blum, Harold F., 1943: Effect of intensity on tumor induction by ultra-violet radiation. Tumor induction in [male] strain A mice by u.-v. radiation is virtually independent of intensity above a certain critical intensity. Below this critical intensity carcinogenic effectiveness falls off sharply. The importance of controlling intensit...

Seyrantepe, V.; Poupetova, H.; Froissart, R.; Zabot, M-Thérèse.; Maire, Iène.; Pshezhetsky, A.V., 2003: Molecular pathology of NEU1 gene in sialidosis. Lysosomal sialidase (EC has a dual physiological function; it participates in intralysosomal catabolism of sialylated glycoconjugates and is involved in cellular immune response. Mutations in the sialidase gene NEU1, located on chromosom...

Lamar, R.T.; Evans, J.W.; Glaser, J.A., 1993: Solid-phase treatment of a pentachlorophenol-contaminated soil using lignin-degrading fungi. The abilities of three lignin-degrading fungi, Phanerochaete chrysosporium, Phanerochaete sordida, and Trametes hirsuta, to deplete pentachlorophenol (PCP) from soil contaminated with PCP and creosote were evaluated. A total of seven fungal and th...

Bemmann, A., 2001: Land use for forestry. This paper provides information on the forest conditions, changes in forest property rights, forest use, and forest products certification in Central and Eastern Europe.

Bernard T.N.Jr; Whitecloud T.S.IIi; Haddad R.J.Jr, 1983: Segmental spinal instrumentation in the management of fractures of the thoraco lumbar spine a preliminary report. Orthopaedic Transactions 7(2): 227

Simonne, E.; Kemble, J., 1995: AAES renews vegetable variety trial program. Highlights of agricultural researchng 42(1): 19-20

Mayer, J.S.; Bittner, R.A.; Nikolić, D.; Bledowski, C.; Goebel, R.; Linden, D.E.J., 2007: Common neural substrates for visual working memory and attention. Humans are severely limited in their ability to memorize visual information over short periods of time. Selective attention has been implicated as a limiting factor. Here we used functional magnetic resonance imaging to test the hypothesis that t...